The future of coeliac disease: immunology, environment and possibilities for new treatments.

Recruiting

Conditions: Coeliac sprue
Gluten intolerance
10025477
10003816

Registration Number: NL-OMON44841

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 400

Inclusion Criteria

All children that undergo diagnostic upper gastrointestinal endoscopy under general anesthesia for medical reasons in the Willem-Alexander Children*s Hospital of the LUMC are eligible for the study. Around 120 children undergo upper gastrointestinal endoscopy in the Department of Pediatrics of the LUMC each year. They will be divided in
- Cases: all children that are diagnosed with coeliac disease according to accepted criteria
- Controls: all children that are diagnosed with other conditions unrelated to coeliac disease ;Informed consent and suffiecient knowledge / understanding of the Dutch language are mandatory

Exclusion Criteria

- No informed consent
- Insufficient knowledge / understanding of Dutch language
- Prior participation in protocol P06.140 or the present study if subject has undergone more than one endoscopy.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Definition of the disease associated T cell receptor repertoire in a large<br /><br>group of paediatric patients.<br /><br>Determination of the functional characteristics of the disease associated T<br /><br>cells.<br /><br>Correlation of the disease associated T cell receptor repertoire with disease<br /><br>onset and/or severity<br /><br>Phenotypic and functional characterisation of the intraepithelial lymphocyte<br /><br>compartment in patients with and without CD.<br /><br>Analysis of the cytokine mediated crosstalk between the lamina propria and<br /><br>epithelial compartments.</p><br>

Secondary Outcome Measures