The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 4
- 主要终点
- prevalence of local allergic rhinitis (LAR)
研究概览
简要总结
- To determine prevalence of local allergic rhinitis (LAR)
- To evaluate clinical characteristic and severity of local allergic rhinitis
- To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)
详细描述
Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 8 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year
- •No respiratory infections in the previous 4 weeks
- •No following treatment of
- •systemic corticosteroid 4 weeks
- •intranasal corticosteroid 2 weeks
- •oral antihistamine 1 week
- •leukotriene antagonist 1 week
排除标准
- •Patients with underlying disease:
- •chronic rhinosinusitis and nasal polyp
- •immunological disease
- •chronic renal disease
- •hepatobiliary disease
- •cardiovascular disease
- •Parental withdraw consent
- •Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) < 80% of predicted
研究组 & 干预措施
nonallergic rhinitis
nonallergic rhinitis nasal allergen provocation test
干预措施: nasal allergen provocation test (Procedure)
结局指标
主要结局
prevalence of local allergic rhinitis (LAR)
时间窗: 1 year
positive nasal allergen provocation test with Der p1
次要结局
未报告次要终点
研究者
Orathai Piboonpocanun
Division of allergy and immunology
Mahidol University