The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

Not Applicable

Completed

• Conditions: Other Allergic Rhinitis
• Interventions: Procedure: nasal allergen provocation test

• Registration Number: NCT02271620
• Lead Sponsor: Mahidol University

Brief Summary

* To determine prevalence of local allergic rhinitis (LAR)

* To evaluate clinical characteristic and severity of local allergic rhinitis

* To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)

Detailed Description

Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-09-09
• Study First Submitted QC: 2014-10-19
• Study First Posted: 2014-10-22
• Primary Completion: 2016-03
• Study Completion: 2016-04
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-21
• Last Update Posted: 2018-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

• Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year
• No respiratory infections in the previous 4 weeks
• No following treatment of
• systemic corticosteroid 4 weeks
• intranasal corticosteroid 2 weeks
• oral antihistamine 1 week
• leukotriene antagonist 1 week

Exclusion Criteria

• Patients with underlying disease:
• chronic rhinosinusitis and nasal polyp
• immunological disease
• chronic renal disease
• hepatobiliary disease
• cardiovascular disease
• cancer
• Parental withdraw consent
• Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) < 80% of predicted

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
nonallergic rhinitis	nasal allergen provocation test	nonallergic rhinitis nasal allergen provocation test

Primary Outcome Measures

Name	Time	Method
prevalence of local allergic rhinitis (LAR)	1 year	positive nasal allergen provocation test with Der p1

Trial Locations

Locations (2)

Division of allergy and immunology, Department of pediatric, Siriraj Hospital; 🇹🇭 Bangkoknoi, Bangkok, Thailand

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand