Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to Smell
- Conditions
- Cystic Fibrosis With Other ManifestationsSinusitis
- Interventions
- Other: nasal lavage and sputum collection
- Registration Number
- NCT00803881
- Lead Sponsor
- University of Jena
- Brief Summary
Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
- Detailed Description
The sub-study on the sense of smelling in CF has been finalized in the meantime. Results were published in 2012:
Smell in cystic fibrosis. Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
- Subject has a confirmed diagnosis of cystic fibrosis
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description CF patients of all age groups nasal lavage and sputum collection Longitudinal prospective assessment of upper and lower airway colonization in all patients attended in the Jena University CF centre
- Primary Outcome Measures
Name Time Method Dynamics in CF upper and lower airway colonization with pathogens 10 years longitudinal non-invasive sampling of upper and lower airways in CF
Assessment of ability to smell in CF patients 3 years
- Secondary Outcome Measures
Name Time Method pulmonary function / BMI 10 years
Trial Locations
- Locations (1)
University of Jena - CF-Center
🇩🇪Jena, Germany