Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
- Conditions
- Chronic Rhinosinusitis With Nasal Polyps
- Interventions
- Diagnostic Test: Serum IL_25 and eosinophils in nasal polyp tisuee
- Registration Number
- NCT06459622
- Lead Sponsor
- Katrina Atef Habashy
- Brief Summary
The study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps ( CRSwNP) to oral corticosteroids.
- Detailed Description
Treatment of nasal polyposis is divided into medical or surgical treatment .
Steroids are widely used as the most effective medicine in nasal polyposis. Although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps (CRSwNP), there is lack of effective means of predicting corticosteroid sensitivity in those patients. It was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps( NP) were only between 53.8% and 80%.. Many reports stated that serum and tissue interleukeine 25 (IL 25) and serum and tissue eosinophalia are good predictors to the response of CRSwNP to oral corticosteroids.
Interleukeine 25(IL-25), an important epithelial-derived proinflammatory cytokine, plays various roles in different inflammatory and allergic diseases, such as asthma and atopic dermatitis .
Hong et al demonstrated that the levels of IL-25 in NP tissues and in serum, as well as the NP endoscopic scores, were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones. In general, eosinophilic NPs are pharmacologically glucocorticoid responsive, but non-eosinophilic or neutrophilic CRSwNP is frequently resistant to steroid treatment.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 102
- clinical diagnosis of chronic rhinosinusitis with nasal polyps
-
1-Patients who had taken any steroid , antihistamine or other immune-modulating medications within the past 4 weeks
2- previous nasal and sinus surgery.
3-Allergic Fungal rhinosinusitis.
4-Unilateral rhinosinusitis.
5- Antrochoanal polyps or cystic fibrosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Non sensitive to corticosteroids Serum IL_25 and eosinophils in nasal polyp tisuee Patients who aren't sensitive to corticosteroids have low serum IL-25 Sensitive to corticosteroids Serum IL_25 and eosinophils in nasal polyp tisuee Patients who are sensitive to corticosteroids have high serum IL-25
- Primary Outcome Measures
Name Time Method Serum IL-25 is measured to releave the relation between them and the response of CRSwNP to oral corticosteroids Baseline Serum IL-25 is related to the effect of corticosteroids on CRSwNP
- Secondary Outcome Measures
Name Time Method