Esophageal dysmotility and gastroesophageal reflux in adult ventilated critically ill patients with low and high residual gastric volumes and how it is affected by intravenously administered metoclopramide: a controlled, single center, prospective study using high resolution impedance manometry

Charles University Faculty of Medicine in Pilsen0 个研究点目标入组 16 人开始时间: 2020年9月3日最近更新: 2023年11月20日

试验速览

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33557860/ results (added 10/02/2021)

•Critically ill patients
•1. Informed consent signed by a close relative and retrospectively by the patient when his/her condition allows it
•2. Age of 18 years and above
•3. Mechanically ventilated critically ill patient
•4. Inclusion within 24-48 hours after reaching the enteral nutrition target of 25 kcal/kg/day
•5. Maximum stable dose of noradrenaline up to 0.2 µg/kg/min
•6. Enteral nutrition via nasogastric tube
•Control group
•1. Signed informed consent
•2. Age of 18 years and above

•Critically ill patients:
•1. History of previous surgery on upper gastrointestinal tract
•2. Gastroesophageal reflux disease
•3. Portal hypertension
•4. Active gastrointestinal bleeding
•5. When an acute diagnostic or treatment procedure outside the intensive care unit at the time of HRIM measurements is required
•6. Epilepsy, severe CNS damage or other contraindication for metoclopramide administration
•7. Coagulopathy with INR value above 2.5 and platelets below 30x10e9/L
•8. Pregnancy
•Control group
•1. History of previous surgery on upper gastrointestinal tract
•2. Diagnosed gastroesophageal reflux disease or symptoms thereof, esophageal varices, or other organic esophageal or gastric disorder
•3. Use of chronic medication, other acute or chronic illness
•4. Pregnancy

发起方

Charles University Faculty of Medicine in Pilsen