Insulin-induced microvascular dilatation during a physiological stimulus - Studies in hypertension and obesity. - Microvascular dilatation after endogenous induced hyperinsulinemia

niversiteit Maastricht0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年5月13日

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•Inclusion criteria healthy normotensive subjects : 18-60 years, Caucasian, blood pressure <140/90 mmHg.
•Inclusion criteria obese normotensive subjects: 18-60 years, Caucasian, blood pressure <140/90 mmHg, BMI 30-38kg/m2
•Inclusion criteria hypertensive subjects: 18-60 years, Caucasian, untreated hypertension >140/90mmHg.

•Exclusion criteria for healthy normotensive and hypertensive subjects: Obesity (BMI>27kg/m2), cardiovascular disease (stroke, coronary artery disease, peripheral
•vascular disease, heart failure), diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), pregnancy, and wearing contact lenses.;Exclusion criteria for normotensive obese subjects: cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure), impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), pregnancy, and wearing contact lenses.

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