Ketamine versus magnesium sulphate as an adjuvant to local anesthetics in the peribulbar block for posterior segment surgeries
Phase 2
- Conditions
- Peribulbar block in adult patients undergoing posterior segment surgeries..
- Registration Number
- IRCT20210220050419N1
- Lead Sponsor
- Research Institute of Ophthalmology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 126
Inclusion Criteria
Posterior segment operations
American Society of Anesthesiologist (ASA) physical status I or II
Age: 45-65 years
Axial length: < 25 mm
Exclusion Criteria
Coagulation abnormalities
Impaired mental status
Allergy to any of the study medications
Problems that interfere with surgeon patient communication and cooperation as deafness
Severe cardiac disease, chronic obstructive lung disease, history of sleep apnea, advanced liver or kidney disease
History of chronic use of sedatives, narcotics, alcohol or drug abuse
Patient refusal
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The onset of sensory block. Timepoint: At 1, 2, 3, 4, and 5 min after the block. Method of measurement: A small piece of cotton wool.;The onset of globe akinesia. Timepoint: At 1, 3, 5, 7, and 10 min after the block. Method of measurement: The 3-point scale.;The Duration of lid akinesia. Timepoint: At 1, 2, 3, 4, and 5 h postoperative. Method of measurement: Clinical assessment of regaining full movement.;The duration of globe akinesia. Timepoint: At 1, 2, 3, 4, and 5 h postoperative. Method of measurement: Clinical assessment of regaining full movement.
- Secondary Outcome Measures
Name Time Method Patient satisfaction. Timepoint: After recovery. Method of measurement: 7-point Likert-like verbal rating scale.;Surgeon satisfaction. Timepoint: At the end of surgery. Method of measurement: The 7-point Likert-like verbal rating scale.;The duration of analgesia. Timepoint: At 1, 2, 3, 4, and 5 h postoperative. Method of measurement: The 10-point Visual Analog Scale.;The intraocular pressure. Timepoint: At baseline and 10 minutes after injection of the local anesthetics. Method of measurement: Schiotz tonometer.;Time to start surgery. Timepoint: At 1, 3, 5, 7, and 10 min after the block. Method of measurement: Corneal anesthesia together with an ocular movement score =1 in each direction and an eyelid akinesia score of 0 (total score <5).