The Effect of Magnesium Sulfate Added to Inferior Alveolar Nerve Block on Pain after Lower Third Molar Surgery

Phase 4

Completed

• Conditions: Patient with impacted mandibular third molar; Magnesium sulfate, postoperative pain, third molar, analgesic effect, Inferior alveolar nerve block

• Registration Number: TCTR20210908005
• Lead Sponsor: Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-08
• Study Completion: 2022-07-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

The patients aged between 18 to 35 years old.
-All participants must have a healthy status (ASA class I and II )
-Patients who have at least one impacted lower third molar without any inflammation or pathology that require both bone removal and tooth section.
-Patient who is able to return for follow-up on the scheduled date, 7 days after the surgery.

Exclusion Criteria

-Patient who is allergic to medications used in this study
-Patient during pregnancy or breastfeeding
-Patient with systemic disease contraindicated to magnesium.
-Patient with a psychiatric disorder
-Patient with drug abuse
-Patient with ongoing pain originated from mandibular third molar or orofacial region
-Patient who currently taking medication that effects post-operative pain or magnesium level
-Patient who is unable to write the record form

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative pain intensity at rest 6, 24, 48, and 72 hours after third molar surgery HP-VAS,Postoperative pain intensity on jaw movement 6, 24, 48, and 72 hours after third molar surgery HP-VAS

Secondary Outcome Measures

Name	Time	Method
The success of inferior alveolar nerve block 15 mins after inferior alveolar nerve block and during the operation profound lip numbness within 15 mins after injection and HP-VAS score during operation less than or equal 54 ,Time to first rescue analgesics The duration after surgery until patient reach the level of pain that need analgesic medication Patient reported outcome using a questionnaire,Pain intensity at first analgesic consumption The duration after surgery until patient reach the level of pain that need analgesic medication Patient reported HP-VAS using a questionnaire,The total number of analgesic consumptions 1 week after surgery Patient reported outcome using a questionnaire,The incidence of adverse events from magnesium sulfate 1 week after surgery Patient reported outcome using a questionnaire