Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty

Phase 4

Completed

• Conditions: Serum Bupivacaine Level; Periarticular Block; Total Knee Arthroplasty
• Interventions: Drug: Bupivacaine

• Registration Number: NCT01636869
• Lead Sponsor: Mahidol University

Brief Summary

Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-07-05
• Study First Submitted QC: 2012-07-05
• Study First Posted: 2012-07-10
• Status Verified: 2014-07
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Last Update Submitted: 2014-07-25
• Last Update Posted: 2014-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• age of 30-70 yr
• ASA I-II
• patient undergo total knee arthroplasty under spinal block and single shot femoral nerve block and periarticular block

Exclusion Criteria

• patient's refusal
• allergic to bupivacaine
• body weight less than 50 kg
• liver disease
• heart disease
• coagulopathy
• Hct<35%
• infection at both groin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
bupicavaine	Bupivacaine	-

Primary Outcome Measures

Name	Time	Method
plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block	2 hours

Secondary Outcome Measures

Name	Time	Method
bupivacaine toxicity	24 hr

Trial Locations

Locations (1)

Faculty of Medicine, Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand