The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Chang Gung University
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Motor evoked potential
Study Overview
Brief Summary
Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown.
This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Clinical diagnosis of Parkinson disease
Exclusion Criteria
- •Clinical diagnosis of other neurological diseases
- •Been diagnosed with any mental illness
- •History of seizures
- •Brain trauma
- •Body with a pacemaker or other electrical stimulator
- •Pregnancy
Arms & Interventions
intervention group
intervention group which receive auditory cueing while performing movement
Intervention: rhythmic auditory stimulation (Procedure)
Control group
control group which performing movement after listen to required movement rhythm.
Outcomes
Primary Outcomes
Motor evoked potential
Time Frame: Baseline,45-60 minute
Use single-pulse TMS to assess Motor evoked potential change.
Finger Tapping
Time Frame: Baseline,45-60 minutes.
Record pre-test and post-test change.
Intracortical inhibition & Intracortical facilitation
Time Frame: Baseline,45-60 minutes
Use paired-pulse TMS to record pre-test and post-test change.
Blood oxygen dependent level
Time Frame: Baseline, in experiment,45-60 minutes
Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.
Secondary Outcomes
No secondary outcomes reported
Investigators
Ya-Ju Chang
Profesor
Chang Gung University