Identification of structural, functional, and metabolic brain alterations in Parkinson's disease and essential tremor using ultra-high-field MRI

• Conditions: G25.0; Essential tremor; G20.00

• Registration Number: DRKS00027008
• Lead Sponsor: niversitätsklinikum der RWTH AachenKlinik für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ET and PD patients: Age>=18 years, diagnosis of either PD or ET made by a movement disorder specialist according to established criteria, sufficient mental abilty and German language skills to undertand the purpose and potential risks of the study, right-handedness

Healthy volunteers: Age >= 18 years, sufficient mental abilty and German language skills to undertand the purpose and potential risks of the study, right-handedness

Exclusion Criteria

neurological diseases other than ET or PD with the exception of mild depression and REM sleep behavior disorder in PD patients, traumatic brain injury, pregnancy, breast feeding period, orthopedic conditions that wopuld prevent participant from lying flat in the MRI scanner, relevant medical condicitons such as severe heart disease or severe diabetes, drug- or alcohol addiction, contraindication for MRI (e.g. cardiac pacemaker, insuline pump, metal implants, severe claustrophobia etc.)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Gamma-aminobutyric acid concentration in the thalamus as assesed by sepctroscopy 2) Brain structure as assesed by anatomical imaging (MP2RAGE) 3) Brain activity during rest as assessed by EPIC based sequence 4) Brain water content as assessed by GRE sequence. All measures will be obtained via cranial MRI.