Image-Based Structural and Functional Phenotyping of the COSYCONET Cohort Using MRI and CT (MR COPD).
- Conditions
- J44Other chronic obstructive pulmonary disease
- Registration Number
- DRKS00005072
- Lead Sponsor
- niversitätsklinikum HeidelbergAbt. Für Diagnostsiche und Interventionelle Radiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 602
Inclusion Criteria
The trial is fully embedded within the main cohort of the COSYCONET-study:
Key inclusion criteria
- Male or female
- Age >40 years
- Diagnosis of COPD (GOLD criteria)
- Available for repeated study visits
Exclusion Criteria
Having undergone lung surgery (e.g., lung volume reduction, lung transplant); Moderate or severe exacerbation within the last 4 weeks prior to visit 1; Unable to understand the intention of the project; lack of signed informed consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary goal of this prospective trial is to demonstrate the capability of MRI to replace CT for the characterization of COPD by structural and functional phenotyping” on a regional basis. The sensitivity and specificity of MRI will be determined by comparison with CT, serving as the gold standard.
- Secondary Outcome Measures
Name Time Method Secondary endpoints are: Relative frequency of completed MRI examinations with diagnostic quality; agreement of visual and software-based phenotyping; comparative assessment of pulmonary functional reserve by perfusion MRI, pulmonary function tests (TLCO); and the six-minute walk test (6 MWT); and extrapulmonary disease manifestations.<br>