Multimodal imaging genetics features and neuromodulatory mechanisms of facial emotion recognition deficits in schizophrenia
- Conditions
- schizophrenia
- Registration Number
- ChiCTR2400088864
- Lead Sponsor
- Peking University Sixth Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
The inclusion criteria for SCZ patients were as follows: (1) Han nationality, male or female, aged 18 to 55 years; (2) right-handed according to the handedness questionnaire; (3) meeting the clinical diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5); (4) education level = 9 years, no language communication barriers, and able to cooperate with assessment and treatment; (5) written informed consent was obtained from the patient. If the patient was incapable of acting during the onset period, written informed consent from his or her legal guardian was required.<br><br>The inclusion criteria for healthy subjects were as follows: (1) Han nationality, aged 18 to 55 years; (2) right-handed according to the handedness questionnaire; (3) education years = 9 years.
Exclusion criteria for SCZ patients included: (1) patients who met the DSM-5 diagnostic criteria for schizoaffective disorder, depressive disorder, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, memory impairment or other cognitive impairment; (2) patients with severe unstable physical illness, organic brain disease (such as ischemic stroke, cerebral hemorrhage, brain tumor, etc.) or history of severe brain trauma, narrow-angle glaucoma; (3) patients with a history of alcohol or substance abuse/dependence in the past year; (4) patients with a history of epilepsy (at least 2 unprovoked epileptic seizures with an interval of more than 24 hours, or a diagnosis of epilepsy syndrome, or epileptic seizures in the past 12 months) or febrile convulsions; (5) patients with a history of loss of consciousness for more than 5 minutes; (6) patients with a history of suicide attempts, serious suicidal thoughts/behaviors or risk of harming others; (7) patients who had received electroconvulsive therapy (ECT) or rTMS in the past 3 months; (8) pregnant or breastfeeding women, or those planning to become pregnant; (9) Patients with pacemakers, cochlear implants or other metal foreign bodies and any electronic devices implanted in the body, or patients with contraindications to MRI such as claustrophobia; (10) Patients with contraindications to rTMS treatment such as those who cannot tolerate magnetic stimulation or have skin ulcers at the treatment site; (11) Patients with a history of epilepsy (at least 2 uninduced epileptic seizures with an interval of more than 24 hours, or diagnosed with epilepsy syndrome, or epileptic seizures in the past 12 months); (12) Patients currently participating in clinical trials of other drugs or physical therapies (such as deep brain stimulation, electroconvulsive therapy, rTMS); (13) Patients deemed unsuitable by researchers.<br><br>Exclusion criteria for healthy subjects included: (1) the individual or first-degree relatives had any mental disorder that met the diagnostic criteria of DSM-5; (2) had severe unstable physical illness, organic brain disease (such as ischemic stroke, cerebral hemorrhage, brain tumor, etc.) or history of severe brain trauma, narrow-angle glaucoma; (3) had a history of alcoholic substance abuse/dependence in the past year; (4) had a history of epilepsy (at least 2 unprovoked epileptic seizures with an interval of more than 24 hours, or diagnosed with epilepsy syndrome, or had epileptic seizures in the past 12 months), or febrile convulsions; (5) had a history of loss of consciousness for more than 5 minutes; (6) had a history of suicide attempts, serious suicidal thoughts or behaviors; (7) were pregnant or breastfeeding women, or were planning to become pregnant; (8) had a pacemaker, cochlear implant, or other metal foreign body, or any electronic device implanted in the body, or had contraindications to MRI scanning such as claustrophobia; (9) were considered unsuitable for participation by the researchers.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Positive and Negative Syndrome Scale;Personal and Social Performance Scal;Clinical Global Impression- Improvement;Treatment Emergent Symptom Scale;
- Secondary Outcome Measures
Name Time Method