Influence of dexamethasone on postoperative analgesia after combined spinal epidural for cesarean delivery.

• Conditions: Postoperative pain; Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]

• Registration Number: EUCTR2012-001349-41-BE
• Lead Sponsor: AZ Groeninge

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02-19
• Last Update Posted: 25 February 2013

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Age>18
Elective cesarean section
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 150
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

age<18 years, preterm gestation (<37w), multiple gestations, contraindications for neuraxial anesthesia, intolerance to any of the study drugs, chronic steroid use, chronic opioid use and diabetes.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Is the administration of epidural or intravenous dexamethasone beneficial for postoperative analgesia after cesarean section.;Secondary Objective: Is the administration of epidural or intravenous dexamethasone benificial in the development of postoperative nausea and vomiting after cesarean section.<br><br>Does the administration of epidural or intravenous dexamethasone prevents the development of chronic pain after cesarean section. ;Primary end point(s): Postoperative Analgesic need;Timepoint(s) of evaluation of this end point: 48 hours

Secondary Outcome Measures

Name	Time	Method
Secondary end point(s): Pain scores (Visual analogue score)<br>Postoperative nausea and vomiting score<br>Development of chronic pain;Timepoint(s) of evaluation of this end point: 48 hours (pain scores/nausea and vomiting)<br>6months/ 1 year (develoment of chronic pain)