Analgesic efficacy of perioperative dexamethasone when combined with nefopam in NSAIDs-based gynecological surgery: a randomized, double-blind study

Phase 3

• Conditions: Transabdominal hysterectomy is the most common gynecologic surgery. It also associates with moderate to severe postoperative pain. Multimodal analgesia is the best technique for pain control and impro; dexamethasone, nefopam, multimodal analgesia, transabdominal hysterectomy

• Registration Number: TCTR20201215002
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-15
• Study Completion: 2021-08-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

Female
Age 20 -65 years old
Undergoing TAH +/- BSO
ASA physical status 1 or 2
Elective case

Exclusion Criteria

BMI > 35 kg/m2
Underlying disease: liver failure, renal failure, cardiac disease, psychiatric disorder
Creatinine clearance < 30 ml/min
History of seizure
Chronic pain syndrome
Allergy to Morphine, Dexamethasone, Nefopam, Parecoxib
Inability to understand VNRS and/or control IV-PCA

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total dose requirement of morphine via IVPCA in postoperative phase at 24 hour milligram

Secondary Outcome Measures

Name	Time	Method
Verbal Numerical Rating Scale (VNRS) at 0, 1, 6, 12, 24 hour Numeric of pain score,adverse effects: nausea and vomiting, dyspepsia, hyperglycemia at 24 hour percentage