IRCT20110628006907N15
Not yet recruiting
未知
Evaluation of the effectiveness of intrathecal injection of allogeneic umbilical cord derived mesenchymal stem cells in the phenotypic changes of Spinal Muscular Atrophy type I, II and III in comparison with control group, A Clinical trial phase I, II
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Spinal Muscular Atrophy Type 1-2 3.
- Sponsor
- Tehran University of Medical Sciences
- Enrollment
- 60
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Genetically confirmed deletion of SMN1 gene for the diagnosis of SMA disease, SMN2 gene copy number count for the diagnostic classification of disease type, Minimum age of 6 months in type I, Ventilator independent patients at the beginning of treatment in type I, Maximum age of 16 years in type II and III, Ventilator independent patients in type II and III, Absence of brain damage, Absence of liver disease, Absence of renal disease, Absence of hematological disease, Informed consent of patients and their parents
Exclusion Criteria
- •Acquired brain damage including hypoxia, ?Structural and functional brain disorders, Acute infections such as( HCV, HIV,HBV), Malignancies, Hemorrhagic diathesis, Severe anemia ( Hb less than 8 gram/dl), Renal dysfunction, Hepatic dysfunction
Outcomes
Primary Outcomes
Not specified
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