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临床试验/CTRI/2025/03/081633
CTRI/2025/03/081633尚未招募2/3 期

A COMPARATIVE CLINICAL STUDY ON THE EFFICACY OF AROHANA KRAMA AND SADHARANA KRAMA MATRA BASTI WITH KARASKARA GHRITA IN THE MANAGEMENT OF JANU SANDHIGATA VATA-OSTEOARTHRITIS OF KNEE JOINT

Dr Akshara K Narayanan1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年3月11日最近更新:

试验速览

阶段
2/3 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
1.Improvement in Range of motion measured by Goniometry.

研究概览

简要总结

Osteoarthritis is a prevalent degenerative joint disease characterized by pain,swelling and stiffness,affecting a person’s ability to move freely .In 2019 WHO mentions about 528 million people worldwide suffered from Osteoarthritis that is almost 113% increase since 1990 and it is still increasing in present era. It commonly affects weight-bearing joints such as the knees, hips, and spine. While it can occur at any age, it’s more common in older adults due to wear and tear over time. Symptoms often worsen over time, impacting daily activities and quality of life.

 Janu Sandhigata Vata is primarily caused by an imbalance of Vata dosha, the principle of movement and change in the body. Matravasti is an effective therapy for pacifying Vata dosha by restoring balance to Vata dosha. The medicated oils used in Matravasti are specifically chosen for their ability to nourish and strengthen the tissues of the knee joint. By nourishing the joint tissues, Matravasti supports the repair and regeneration of damaged cartilage and other structures affected by Janu Sandhigata Vata.As Sandhigata Vata is Asthi asrita vyadhi in which Acharya Susrutha have mentioned the use of Snehana ie,both Bahya and Abhyantara,as Matravasti is one among sneha basti and can be administered in all age groups without any restrictions in any climatic condition it can be considered as the best management principle in treating Janu Sandhigata Vata.Karaskara Ghrita relieves pain and swelling in inflammatory disorders. It heals and nourishes the degenerative joints mentioned in Sahasrayogam. In this study Matravasti is administered in two different methods ie,Arohana krama(increasing order) mentioned in Adhamalla’s commentry on Sharangathara Samhita and Sadharana krama(fixed dose). Hence an attempt is made to evaluate the effect of Matrav**asti in A**rohana and S**adharana krama in J**anusandhigata V**ata patients.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
40.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Patients with signs and symptoms of janusandhigatavata
  • Patient fit for Matrabasti karma
  • Patient between the age group of 40 and 70 years
  • No discrimination of gender and chronicity.

排除标准

  • Patient below 40 and above 70 years are excluded 2.Systemic diseases like Uncontrolled Diabetes, Uncontrolled Hypertension, Carcinoma, Tuberculosis,Fractured knee.
  • Patient having Ama laksha
  • Patient suffering with Arsha, gudabhramsha, parikartika.

结局指标

主要结局

1.Improvement in Range of motion measured by Goniometry.

时间窗: 0th day (before treatment - 1st assessment) 10th day (after treatment - 2nd assessment) | FOLLOW UP-1st Follow up on 28thday( Final assessment)

2.Reduction of pain is measured by using VAS(Visual Analog Scale).

时间窗: 0th day (before treatment - 1st assessment) 10th day (after treatment - 2nd assessment) | FOLLOW UP-1st Follow up on 28thday( Final assessment)

3.Reduction in the Swelling is measured by using Measurement tape.

时间窗: 0th day (before treatment - 1st assessment) 10th day (after treatment - 2nd assessment) | FOLLOW UP-1st Follow up on 28thday( Final assessment)

次要结局

  • Improvement in the quality of life by reducing the pain, dependency and improving the functionality related to knee joint.(WOMAC questionnaire).(0th day (before treatment - 1st assessment) 10th day (after treatment - 2nd assessment))

研究者

发起方
Dr Akshara K Narayanan
申办方类型
Other [(self)]
责任方
Principal Investigator
主要研究者

Dr Akshara K Narayanan

Shri Dharmasthala Manjunatheshwara Institute of Ayurveda College and Hospital

研究点 (1)

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