Resistance training with Partial Vascular Occlusion (VOT) in Inclusion Body Myositis (IBM). A single group interventional study: a pilot study to corroborate prior findings of VOT in the IBM populatio

Not Applicable

Recruiting

• Conditions: Inclusion Body Myositis; Physical Medicine / Rehabilitation - Physiotherapy; Inflammatory and Immune System - Other inflammatory or immune system disorders; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12614000086662
• Lead Sponsor: Sir Charles Gairdner Hospital Physiotherapy Department

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-01-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

Diagnosis of Inclusion Body Myositis
A minimum of household ambulant with or without an aid
Willing to participate exclusively in the studies exercise program (ie not participate in a formal concurrent thigh strengthening program)
Full range of knee extension

Exclusion Criteria

Non-ambulant, unable to walk 10 meters
Peripheral vascular disease and/or compromised lower limb circulation
Coexistent neurological or psychiatric disease
Severe patella-femoral pain, knee osteoarthritis
Unstable medical condition - unstable angina, uncontrolled diabetes, uncontrolled hypertension

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quadriceps strength:<br>Isokinetic and Isometric (at 15 and 90 degrees) using BioDex System 3 Dynamometer <br>[Beginning of trial.<br>Commencement of training with partial occlusion.<br>End of training with partial occlusion<br>3 months following cessation of training.];Mobility: Timed up and Go test (TUG)[Beginning of trial.<br>Commencement of training with partial occlusion.<br>End of training with partial occlusion<br>3 months following cessation of training.];Functional questionnaire: Inclusion Body Myositis Functional Rating Scale (IBM-FRS)[Beginning of trial.<br>Commencement of training with partial occlusion.<br>End of training with partial occlusion<br>3 months following cessation of training.]

Secondary Outcome Measures

Name	Time	Method
Creatine Kinase[Beginning of trial.<br>Commencement of training with partial occlusion.<br>End of training with partial occlusion<br>3 months following cessation of training.];Falls Diary[Beginning of trial.<br>Commencement of training with partial occlusion.<br>End of training with partial occlusion<br>3 months following cessation of training.]