Danger Response in Polytraumatized Patients

• Conditions: V99; S00; S06; S01; S02; S03; S07; S09; R04; R02

• Registration Number: DRKS00017212
• Lead Sponsor: Klinik für Unfall-, Hand- und WiederherstellungschirurgieUniversitätsklinikum Frankfurt der Goethe Universität

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

(Poly)trauma with an ISS = 16
- preclinical time < 120 min
- regular termination of the shock room phase
- informed consent

Exclusion Criteria

- patients younger then 18
- death within 24 hours post trauma
- ISS < 16
- kardiopulmonal reanimation
- gravidity
- patients who underwent immunosuppressive or chemotherapy within the last three months
- Immune suppressive therapy
- HIV, hepatitis A, B, C, HCV, CMV
- kidney dialysis

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- cytokie-/chemokine profiles<br>- coagulation factors <br>- complement factors <br>- cell damage and function marker<br>- DAMPs and PAMPs<br>- cell s<br>- organ functions<br>- diagnoses <br>- duration of the stay at the intensive care unit and hospital<br>- organ failure, mortality

Secondary Outcome Measures

Name	Time	Method
- mediators <br>- stem cells  <br>- cell marker <br>- protein/gene expressions<br>- differential blood analysis <br>- infections<br>- SIRS<br>- sepsis<br>- shock <br>- organ dysfunctions<br>- injury<br>- regenerative disturbances<br>- complications <br>- mortality <br>- transfusion<br>- perioperative complications<br>