Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Association of InterCellular Adhesion Molecule-1 plasma level with 28 days mortality
研究概览
简要总结
The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all adult patients admitted in ICU for covid-19 disease within the past 24 hrs
排除标准
- •bactrial co-infection at admission
- •expected death within the next 24 hrs
- •pregnancy
结局指标
主要结局
Association of InterCellular Adhesion Molecule-1 plasma level with 28 days mortality
时间窗: 24 hours
Plasma of covid-19 patients will be tested for endothelial injuries, notably with the measurement of InterCellular Adhesion Molecule 1 level by Enzym-Linked Immunosorbent Assay. The association of these levels with 28-days mortality will be evaluated as prognosis markers.
次要结局
- Association of Vascular Endothelial Growth Factor A plasma level with 28 days mortality(24 hours)
- Association of von Willebrandt Factor with thrombotic events(24 hours)
- Association of Viscoelastic testing with thrombotic events(24 hours)
- Association of D-dimers plasma levels with thrombotic events(24 hours)
- Association of soluble Vascular Endothelial Growth Factor Receptor type 1 with 28 days mortality(24 hours)
- Association of syndecan -1 plasma level with 28 days mortality(24 hours)
- Association of Endothelin-1 plasma level with 28 days mortality(24 hours)
研究者
EBESNIER
Principal investigator
University Hospital, Rouen