Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid-19
- Sponsor
- University Hospital, Rouen
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Association of InterCellular Adhesion Molecule-1 plasma level with 28 days mortality
- Last Updated
- 5 years ago
Overview
Brief Summary
The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.
Investigators
EBESNIER
Principal investigator
University Hospital, Rouen
Eligibility Criteria
Inclusion Criteria
- •all adult patients admitted in ICU for covid-19 disease within the past 24 hrs
Exclusion Criteria
- •bactrial co-infection at admission
- •expected death within the next 24 hrs
- •pregnancy
Outcomes
Primary Outcomes
Association of InterCellular Adhesion Molecule-1 plasma level with 28 days mortality
Time Frame: 24 hours
Plasma of covid-19 patients will be tested for endothelial injuries, notably with the measurement of InterCellular Adhesion Molecule 1 level by Enzym-Linked Immunosorbent Assay. The association of these levels with 28-days mortality will be evaluated as prognosis markers.
Secondary Outcomes
- Association of Vascular Endothelial Growth Factor A plasma level with 28 days mortality(24 hours)
- Association of von Willebrandt Factor with thrombotic events(24 hours)
- Association of Viscoelastic testing with thrombotic events(24 hours)
- Association of D-dimers plasma levels with thrombotic events(24 hours)
- Association of soluble Vascular Endothelial Growth Factor Receptor type 1 with 28 days mortality(24 hours)
- Association of syndecan -1 plasma level with 28 days mortality(24 hours)
- Association of Endothelin-1 plasma level with 28 days mortality(24 hours)