Influence of COVID-19 on Vascular Endothelial Function
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID
- Sponsor
- Radboud University Medical Center
- Enrollment
- 203
- Locations
- 1
- Primary Endpoint
- Endothelial dysfunction
- Last Updated
- 4 years ago
Overview
Brief Summary
Rationale: Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) 2 could result in endothelial dysfunction with increased risk of arterial thrombotic events by downregulating the expression of angiotensin converting enzyme 2 (ACE2). Endothelial function can be easily and non-invasively determined by carotid artery reactivity (CAR) testing.
Objective: To investigate the predictive value of endothelial dysfunction, measured by carotid artery reactivity testing, for 1-year cardiovascular events in patients with past COVID-19 infection.
Study design: A prospective observational longitudinal cohort study.
Study population: Patients recovered from confirmed infection with SARS-CoV2.
Main study parameters/endpoints: macrovascular endothelial function measured by carotid artery reactivity testing.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Confirmed SARS-CoV2 infection by polymerase chain reaction on nasopharyngeal swab, sputum or bronchoalveolar lavage.
- •At least 6 and no more than 20 weeks after resolution of COVID-19 related symptoms
- •≥ 16 years old
Exclusion Criteria
- •Recent (\<3 months) angina pectoris, myocardial infarction, stroke, or heart failure
- •Raynaud syndrome, scleroderma, complex regional pain syndrome of the upper extremity or presence of arteriovenous fistula or open wounds on both the upper extremities.
Outcomes
Primary Outcomes
Endothelial dysfunction
Time Frame: CAR will be measures between 6 and 20 weeks and 1 year after recovery from COVID-19.
Change in endothelial dysfunction as determined by CAR test.
Secondary Outcomes
- Major adverse cardiovascular events (MACE)(1 year)