A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)
- Conditions
- Small Cell Lung Cancer
- Interventions
- Drug: Placebo for rovalpituzumab tesirine
- Registration Number
- NCT03033511
- Lead Sponsor
- AbbVie
- Brief Summary
This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based chemotherapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 748
- Histologically or cytologically confirmed extensive-stage disease small cell lung cancer (ED SCLC) at initial diagnosis with ongoing clinical benefit (stable disease [SD], partial response [PR], or complete response [CR]) following completion of 4 cycles of first-line platinum-based therapy
- Participant is eligible to be randomized at least 3 but no more than 9 weeks from Day 1 of the fourth cycle of first-line platinum-based chemotherapy.
- Participants with a history of central nervous system (CNS) metastases prior to the initiation of first-line platinum-based chemotherapy must have received definitive local treatment and have documentation of stable or improved CNS disease status
- Eastern Cooperative Oncology Group (ECOG) performance score of 0 or 1
- Participants must have adequate bone marrow, renal and hepatic function
- Availability of archived or representative tumor material for assessment of DLL3 expression
- Any prior systemic chemotherapy, small molecule inhibitors, immune checkpoint inhibitors, other monoclonal antibodies, antibody-drug conjugates, radioimmunoconjugates, T-cell or other cell-based or biologic therapies, or any other anti-cancer therapy than that described in inclusion criteria for SCLC.
- Any disease-directed radiotherapy (except prophylactic cranial irradiation, palliative radiotherapy to a radiographically documented non-progressing lesion for symptom control, or pre-planned radiotherapy for CNS metastases present prior to start of first-line therapy and non-progressing) after last dose of first-line chemotherapy.
- Prior exposure to a pyrrolobenzodiazepine (PBD-based) or indolinobenzodiazepine-based drug, prior participation in a rovalpituzumab tesirine clinical trial, or known hypersensitivity or other contraindications to rovalpituzumab tesirine or excipient contained in the drug formulation.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo for dexamethasone Placebo q6 wk; omitting every third cycle Placebo Placebo for rovalpituzumab tesirine Placebo q6 wk; omitting every third cycle Rovalpituzumab tesirine/dexamethasone Dexamethasone Rovalpituzumab tesirine/dexamethasone every 6 weeks (q6 wk); omitting every third cycle Rovalpituzumab tesirine/dexamethasone Rovalpituzumab tesirine Rovalpituzumab tesirine/dexamethasone every 6 weeks (q6 wk); omitting every third cycle
- Primary Outcome Measures
Name Time Method Overall Survival (OS) in Participants With Extensive-Stage Small Cell Lung Cancer With Delta-Like Protein 3 High Expression in Tumor (DLL3high) Survival follow-up continued until the endpoint of death, participant was lost to follow-up or withdrew consent, or termination of the study by AbbVie, whichever occurred first. Median time on study overall was 11.9 months. OS is defined as the number of months from randomization to death of any cause. Calculated using the Kaplan-Meier methodology.
- Secondary Outcome Measures
Name Time Method OS in All Randomized Participants Survival follow-up continued until the endpoint of death, the subject was lost to follow-up or withdrew consent, or termination of the study by AbbVie, whichever occurred first. Median time on study overall was 11.9 months. OS is defined as the number of months from randomization to death of any cause. Calculated using the Kaplan-Meier methodology.
Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) Physical Functioning Domain Over Time Baseline, Weeks 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, 66, 72, 78, Final Visit (up to Week 78) The EORTC QLQ-C30 is composed of global health status/QoL scale; five functional domains (physical, role, emotional, cognitive, and social); three symptom domains (fatigue, nausea and vomiting, and pain); and six single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties).
The Physical Functioning domain includes 5 questions in which participants were asked to rate their overall health and overall quality of life as it relates to physical functioning during the past week on a scale from 1 (very poor) to 7 (excellent). The 5 scores were averaged and transformed to a scale from 0 to 100, where a high score represents a high QoL. A positive change from baseline indicates better quality of life.
Trial Locations
- Locations (308)
Parkland Health and Hosp Syste /ID# 170933
🇺🇸Dallas, Texas, United States
LA Hem-Oncology Med Group /ID# 156717
🇺🇸Los Angeles, California, United States
Thomas Jefferson University /ID# 156719
🇺🇸Philadelphia, Pennsylvania, United States
St Jude Hospital dba St Joseph /ID# 156526
🇺🇸Santa Rosa, California, United States
Eastern Carolina University /ID# 159264
🇺🇸Greenville, North Carolina, United States
Ingalls Memorial Hosp /ID# 156685
🇺🇸Harvey, Illinois, United States
Northwell Health - Monter Cancer Center /ID# 159252
🇺🇸Lake Success, New York, United States
Gabrail Cancer Center Research /ID# 156667
🇺🇸Canton, Ohio, United States
MD Anderson Cancer Center at Cooper - Camden /ID# 156681
🇺🇸Camden, New Jersey, United States
Sparrow Regional Cancer Center, Sparrow Health System /ID# 156590
🇺🇸Lansing, Michigan, United States
Icri /Id# 157765
🇺🇸Whittier, California, United States
Brampton Civic Hospital /ID# 204425
🇨🇦Brampton, Ontario, Canada
NorthShore University HealthSystem - Evanston Hospital /ID# 156664
🇺🇸Evanston, Illinois, United States
Kaiser Permanente Lone Tree /ID# 159331
🇺🇸Lone Tree, Colorado, United States
Stony Brook University Hospital /ID# 159272
🇺🇸Stony Brook, New York, United States
Southeastern Regional Medical /ID# 163064
🇺🇸Newnan, Georgia, United States
Ashland-Bellefonte Cancer Ctr /ID# 202901
🇺🇸Ashland, Kentucky, United States
St. Luke's Mountain States Tumor Institute - Boise /ID# 156691
🇺🇸Boise, Idaho, United States
Ochsner Clinic Foundation /ID# 159136
🇺🇸Baton Rouge, Louisiana, United States
Nemocnice Rudolfa a Stefanie /ID# 159655
🇨🇿Benesov, Czechia
Shizuoka Cancer Center /ID# 166272
🇯🇵Sunto-gun, Shizuoka, Japan
Klinicki bolnicki centar Sestre milosrdnice /ID# 159090
🇭🇷Zagreb, Grad Zagreb, Croatia
FN Plzen /ID# 204097
🇨🇿Plzen, Czechia
KH Martha-Maria Halle Dolau /ID# 158794
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
Fujian Provincial Cancer Hospital /ID# 204864
🇨🇳Fuzhou, Fujian, China
CHU Hopital Nord /ID# 160543
🇫🇷Marseille, Bouches-du-Rhone, France
Asklepios Fachkliniken M. Gaut /ID# 158789
🇩🇪Gauting, Germany
Iucpq-Ul /Id# 159530
🇨🇦Québec, Quebec, Canada
Nemocnice Horovice a.s. /ID# 161186
🇨🇿Horovice, Czechia
Oblastni Nemocnice Pribram /ID# 159654
🇨🇿Pribram, Czechia
Lungenklinik Hemer /ID# 158790
🇩🇪Hemer, Germany
Hopital Tenon /ID# 160541
🇫🇷Paris, France
Klinikum Kassel /ID# 158786
🇩🇪Kassel, Germany
Windsor Regional Cancer Centre /ID# 170869
🇨🇦Windsor, Ontario, Canada
University General Hospital of Heraklion PA.G.N.I /ID# 202409
🇬🇷Heraklion, Greece
Soroka University Medical Center /ID# 159762
🇮🇱Be'er Sheva, Israel
Assaf Harofeh Medical Center /ID# 201883
🇮🇱Be'er Ya'akov, Israel
Charite Universitatsmedizin Berlin Campus Virchow Klinikum /ID# 158783
🇩🇪Berlin, Germany
Hopital Larrey /ID# 204290
🇫🇷Toulouse, France
East Tallinn Central Hospital /ID# 160019
🇪🇪Tallinn, Estonia
Docrates Cancer Center /ID# 159591
🇫🇮Helsinki, Finland
Vitkovicka nemocnice a. s. /ID# 161187
🇨🇿Ostrava, Czechia
Institut Curie /ID# 207514
🇫🇷Paris CEDEX 05, Ile-de-France, France
Evangelische Lungenklinik Berl /ID# 158935
🇩🇪Berlin, Germany
A.O.U. San Luigi Gonzaga /ID# 158916
🇮🇹Orbassano, Italy
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 158962
🇭🇺Miskolc, Borsod-Abauj-Zemplen, Hungary
Beaumont Hospital /ID# 159711
🇮🇪Dublin, Ireland
University Hospital Waterford /ID# 159713
🇮🇪Waterford, Ireland
Hadassah /ID# 159763
🇮🇱Jerusalem, Israel
Kansai Medical University Hospital /ID# 165054
🇯🇵Hirakata-shi, Osaka, Japan
Klinik Loewenstein GmbH /ID# 158870
🇩🇪Löwenstein, Germany
Fachkliniken Wangen /ID# 160779
🇩🇪Wangen, Germany
Asan Medical Center /ID# 159299
🇰🇷Seoul, Korea, Republic of
Cork University Hospital /ID# 159715
🇮🇪Cork, Ireland
Ospedale Santa Maria delle Cro /ID# 158911
🇮🇹Ravenna, Italy
National Cancer Institute /ID# 160017
🇱🇹Vilnius, Lithuania
Yokohama City University Hospital /ID# 165746
🇯🇵Yokohama-shi, Kanagawa, Japan
Hokkaido Cancer Center /ID# 165236
🇯🇵Sapporo, Japan
Kanagawa Cancer Center /ID# 165814
🇯🇵Yokohama, Japan
Kurume University Hospital /ID# 164595
🇯🇵Kurume-shi, Fukuoka, Japan
Meander Medisch Centrum /ID# 159064
🇳🇱Amersfoort, Netherlands
Wakayama Medical University /ID# 165946
🇯🇵Wakayama-shi, Wakayama, Japan
Severance Hospital /ID# 159297
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital /ID# 159302
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Sheba Medical Center /ID# 159760
🇮🇱Ramat Gan, Israel
National Hospital Organization Himeji Medical Center /ID# 165899
🇯🇵Himeji, Japan
Japanese Red Cross Okayama Hospital /ID# 165157
🇯🇵Okayama-shi, Okayama, Japan
Tel Aviv Sourasky Medical Center /ID# 161467
🇮🇱Tel Aviv-Yafo, Tel-Aviv, Israel
Hospital Universitario Vall d'Hebron /ID# 159708
🇪🇸Barcelona, Spain
Meir Medical Center /ID# 159761
🇮🇱Kfar Saba, Israel
Tokushima University Hospital /ID# 166105
🇯🇵Tokushima-shi, Tokushima, Japan
Sendai Kousei Hospital /ID# 166491
🇯🇵Sendai, Japan
AUSL 8 Arezzo Ospedale San Don /ID# 160897
🇮🇹Arezzo, Italy
IFO Istituto Nazionale Tumori /ID# 158912
🇮🇹Rome, Italy
Samsung Medical Center /ID# 159304
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hospital Clinico Universitario San Carlos /ID# 159706
🇪🇸Madrid, Spain
Kanazawa University Hospital /ID# 165127
🇯🇵Kanazawa, Ishikawa, Japan
Mary Potter Oncology Centre /ID# 158877
🇿🇦Pretoria, Gauteng, South Africa
Klaipeda University Hospital /ID# 160018
🇱🇹Klaipeda, Lithuania
Osaka City General Hospital /ID# 165714
🇯🇵Osaka, Japan
Kindai University Hospital /ID# 166395
🇯🇵Osaka-sayama-shi, Osaka, Japan
Matsusaka City Hospital /ID# 166156
🇯🇵Matsusaka-shi MIE, Japan
Chungbuk National University /ID# 159300
🇰🇷Cheongju-si, Korea, Republic of
Akdeniz Universitesi Tip Fakul /ID# 160791
🇹🇷Antalya, Turkey
Dr. Suat Seren Gogus Has /ID# 159244
🇹🇷Izmir, Turkey
St. George's Healthcare NHS /ID# 202416
🇬🇧London, United Kingdom
Dr Albert, Bouwer and Jordaan Incorporated /ID# 158873
🇿🇦Pretoria, Gauteng, South Africa
Hospital da Luz, SA /ID# 159954
🇵🇹Lisbon, Portugal
Cancercare Outeniqua Oncology Unit /ID# 200689
🇿🇦George, Western Cape, South Africa
IPO Porto FG, EPE /ID# 159956
🇵🇹Porto, Portugal
Kaluga Regional Clinical Oncol /ID# 160180
🇷🇺Kaluga, Russian Federation
Hospital Parc de Salut del Mar /ID# 159690
🇪🇸Barcelona, Spain
Bezmi alem Vakif Universitesi /ID# 202267
🇹🇷Istanbul, Turkey
Hospital Regional de Malaga /ID# 164371
🇪🇸Málaga, Malaga, Spain
Centralsjukhuset, Karlstad /ID# 163451
🇸🇪Karlstad, Varmlands Lan, Sweden
Sahlgrenska US Gbg /ID# 159524
🇸🇪Göteborg, Vastra Gotalands Lan, Sweden
University Hospital Linkoping /ID# 159046
🇸🇪Linkoping, Sweden
Queen Elizabeth Medical Centre /ID# 162899
🇬🇧Birmingham, United Kingdom
Colchester General Hospital /ID# 159042
🇬🇧Colchester, United Kingdom
Maidstone Hospital /ID# 159043
🇬🇧Maidstone, United Kingdom
Hospital Universitario La Paz /ID# 159692
🇪🇸Madrid, Spain
Hospital Teresa Herrera - CHUAC /ID# 164368
🇪🇸A Coruña, A Coruna, Spain
National Cheng Kung University Hospital /ID# 158799
🇨🇳Tainan City, Tainan, Taiwan
Dalin Tzu Chi General Hospital /ID# 158983
🇨🇳Dalin Township, Taiwan
Hospital Universitario Fundacion Jimenez Diaz /ID# 159693
🇪🇸Madrid, Spain
Uppsala University Hospital /ID# 159052
🇸🇪Uppsala, Sweden
Charing Cross Hospital /ID# 161399
🇬🇧London, United Kingdom
Ataturk Gogus Hastalikl /ID# 159556
🇹🇷Ankara, Turkey
Inonu University /ID# 159245
🇹🇷Malatya, Turkey
Ege University Medical Faculty /ID# 159243
🇹🇷Izmir, Turkey
Hereford County Hospital /ID# 159038
🇬🇧Hereford, United Kingdom
Christie NHS Foundation Trust /ID# 159037
🇬🇧Manchester, United Kingdom
The Royal Bournemouth Hospital /ID# 159039
🇬🇧Bournemouth, United Kingdom
Houston Methodist Hospital - Scurlock Tower /ID# 202323
🇺🇸Houston, Texas, United States
Rijnstate /ID# 159063
🇳🇱Arnhem, Netherlands
Amphia Ziekenhuis /ID# 159065
🇳🇱Breda, Netherlands
Catharina Ziekenhuis /ID# 158082
🇳🇱Eindhoven, Netherlands
Maastricht Universitair Medisch Centrum /ID# 161669
🇳🇱Maastricht, Netherlands
Jeroen Bosch Ziekenhuis /ID# 158081
🇳🇱S Hertogenbosch, Netherlands
Universitair Medisch Centrum Utrecht /ID# 158083
🇳🇱Utrecht, Netherlands
Duke University Medical Center /ID# 156706
🇺🇸Durham, North Carolina, United States
Harbin Medical University Cancer Hospital /Id# 203638
🇨🇳Harbin, Heilongjiang, China
Jilin Cancer Hosptial /ID# 204060
🇨🇳Changchun, Jilin, China
The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203641
🇨🇳Urumqi, Xinjiang, China
Hubei Cancer Hospital /ID# 202886
🇨🇳Wuhan, Hubei, China
Sir Run Run Shaw Hospital /ID# 206802
🇨🇳Jianggan Hangzhou, Zhejiang, China
4th Military Medical Universit /ID# 203986
🇨🇳Xi'an, China
Henan Cancer Hospital /ID# 204636
🇨🇳Zhengzhou Henan, China
St. James's Hospital /ID# 159712
🇮🇪Dublin 8, Dublin, Ireland
Liga Norte Rio Grandense Cont. /ID# 159011
🇧🇷Natal, Rio Grande Do Norte, Brazil
Associação Hospital de Caridade Ijuí - Centro de Tratamento de Cancer - CACON /ID# 159013
🇧🇷Ijuí, Rio Grande Do Sul, Brazil
Hospital Sao Lucas da PUCRS /ID# 159662
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
The Oncology Centre /ID# 158872
🇿🇦Durban, Kwazulu-Natal, South Africa
Henry Ford Health System /ID# 156712
🇺🇸Detroit, Michigan, United States
Tennessee Oncology-Nashville Centennial /ID# 161168
🇺🇸Nashville, Tennessee, United States
Rigshospitalet /ID# 158055
🇩🇰Copenhagen Ø, Hovedstaden, Denmark
Herlev Hospital /ID# 158053
🇩🇰Herlev, Hovedstaden, Denmark
Aalborg University Hospital /ID# 203737
🇩🇰Aalborg, Nordjylland, Denmark
Odense Universitets Hospital /ID# 158054
🇩🇰Odense C, Syddanmark, Denmark
Kaiser Permanente, NW /ID# 201793
🇺🇸Portland, Oregon, United States
Karolinska Univ Sjukhuset /ID# 159649
🇸🇪Solna, Sweden
Hopital Haut-Lévêque /ID# 160547
🇫🇷Pessac CEDEX, Gironde, France
Centre Hosp Intercommunal de Creteil /ID# 162686
🇫🇷Creteil, Val-de-Marne, France
Euromedica General Clinic /ID# 159156
🇬🇷Thessaloniki, Greece
Hopital de Jolimont /ID# 159005
🇧🇪Haine Saint Paul, Belgium
Billings Clinic /ID# 201788
🇺🇸Billings, Montana, United States
LKH-Univ. Klinikum Graz /ID# 159563
🇦🇹Graz, Austria
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159160
🇬🇷Athens, Greece
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 160016
🇱🇹Kovno, Kaunas, Lithuania
British Columbia Cancer Agency /ID# 163721
🇨🇦Surrey, British Columbia, Canada
Policlinico Universitario Campus Bio-Medico /ID# 160874
🇮🇹Rome, Lazio, Italy
Metropolitan General Hospital /ID# 202422
🇬🇷Cholargos, Attiki, Greece
Orszagos Koranyi Pulmonologiai Intezet /ID# 158953
🇭🇺Budapest XII, Budapest, Hungary
Queen Elizabeth Hospital /ID# 159565
🇭🇰Kowloon, Hong Kong
General Oncological Hospital /ID# 159159
🇬🇷Nea Kifisia, Greece
St Vincent's University Hosp /ID# 161678
🇮🇪Dublin, Ireland
National Cancer Center Hospital /ID# 166547
🇯🇵Chuo-ku, Tokyo, Japan
Pauls Stradins Clinical /ID# 158715
🇱🇻Riga, Latvia
Centro de Investigación Clinica Chapultepec /ID# 160965
🇲🇽Morelia, Michoacan, Mexico
Akershus universitetssykehus /ID# 201682
🇳🇴Nordbyhagen, Akershus, Norway
Haukeland University Hospital /ID# 159573
🇳🇴Bergen, Hordaland, Norway
Radiumhospitalet, OUS /ID# 159574
🇳🇴Oslo, Norway
Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 159604
🇵🇱Rzeszów, Podkarpackie, Poland
Szpitale Pomorskie Sp. z o.o /ID# 159605
🇵🇱Gdynia, Poland
Health Pharma professional Ser /ID# 160734
🇲🇽Ciudad de México, Mexico
St. Olavs Hospital HF /ID# 163110
🇳🇴Trondheim, Sor-Trondelag, Norway
IPO Lisboa FG, EPE /ID# 159949
🇵🇹Lisboa, Portugal
LLC Novaya Clinica /ID# 205523
🇷🇺Pyatigorsk, Russian Federation
Institut za onkologiju i radio /ID# 160904
🇷🇸Belgrade, Serbia
Erciyes University Medical Fac /ID# 202269
🇹🇷Melikgazi, Kayseri, Turkey
Centro Hospitalar Lisboa Norte, EPE /ID# 159957
🇵🇹Lisbon, Lisboa, Portugal
N.N. Petrov Research Inst Onc /ID# 159370
🇷🇺St. Petersburg, Russian Federation
Drammen Sykehus /ID# 159572
🇳🇴Drammen, Buskerud, Norway
Stavanger Universitetssykehus /ID# 159575
🇳🇴Stavanger, Norway
Hospital CUF Porto /ID# 159955
🇵🇹Porto, Portugal
Clinical Onco Dispensary /ID# 159365
🇷🇺Omsk, Russian Federation
Smolensk Regional Onc Clin Dis /ID# 159372
🇷🇺Smolensk, Russian Federation
Clinical Center Serbia /ID# 160902
🇷🇸Belgrade, Beograd, Serbia
Wojewodzki Szpital Specjalisty /ID# 159603
🇵🇱Bytom, Poland
Ogarev Mordovia State Univ /ID# 205742
🇷🇺Saransk, Russian Federation
Centro Hospitalar do Porto EPE /ID# 203582
🇵🇹Porto, Portugal
National Medical Research Cntr /ID# 169885
🇷🇺Moscow, Moskovskaya Oblast, Russian Federation
LLC BioEq Ltd. /ID# 159368
🇷🇺St. Petersburg, Russian Federation
Clin Hosp Ctr Bezanijska Kosa /ID# 160903
🇷🇸Belgrade, Beograd, Serbia
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 158798
🇨🇳Kaohsiung, Taiwan
Cancercare Langenhoven Drive Oncology Centre /ID# 159126
🇿🇦Port Elizabeth, Eastern Cape, South Africa
China Medical University Hosp /ID# 158981
🇨🇳Taichung City, Taichung, Taiwan
Hacettepe University Medical Faculty /ID# 159242
🇹🇷Altindağ, Ankara, Turkey
Institute For Pulmonary Diseas /ID# 164250
🇷🇸Sremska Kamenica, Serbia
Cape Town Oncology Trials /ID# 201311
🇿🇦Cape Town, Western Cape, South Africa
Kantonsspital St. Gallen /ID# 160604
🇨🇭St. Gallen, Sankt Gallen, Switzerland
CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159131
🇺🇦Zaporizhzhia, Zaporizka Oblast, Ukraine
Regional Center of Oncology /ID# 159132
🇺🇦Kharkiv, Ukraine
Cheltenham General Hospital /ID# 169096
🇬🇧Cheltenham, Gloucestershire, United Kingdom
National Taiwan Univ Hosp /ID# 159049
🇨🇳Taipei City, Taipei, Taiwan
Tri-Service General Hospital /ID# 158980
🇨🇳Taipei City, Taipei, Taiwan
Kantonsspital Winterthur /ID# 161379
🇨🇭Winterthur, Switzerland
Taichung Veterans General Hosp /ID# 159047
🇨🇳Taichung City, Taiwan
Municipal institution Multifie /ID# 159130
🇺🇦Dnipro, Ukraine
Volyn Regional Medical Oncology Centre /ID# 159133
🇺🇦Lutsk, Ukraine
Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159865
🇺🇦Uzhhorod, Ukraine
PE PMC Acinus, Medical and Diagnostic Center /ID# 165543
🇺🇦Kropyvnytskyi, Ukraine
Torbay Hospital - So Devon HC /ID# 159041
🇬🇧Torquay, United Kingdom
Icahn School of Med Mt. Sinai /ID# 159210
🇺🇸New York, New York, United States
R.S. McLaughlin Durham Regional /ID# 170870
🇨🇦Oshawa, Ontario, Canada
Clearview Cancer Institute /ID# 156699
🇺🇸Huntsville, Alabama, United States
University of South Alabama /ID# 160975
🇺🇸Mobile, Alabama, United States
Marin Cancer Care /ID# 159207
🇺🇸Greenbrae, California, United States
Highlands Oncology Group /ID# 156722
🇺🇸Fayetteville, Arkansas, United States
Ucsd /Id# 157764
🇺🇸La Jolla, California, United States
Memorial Cancer Institute /ID# 156673
🇺🇸Hollywood, Florida, United States
Christiana Care Health Service /ID# 159212
🇺🇸Newark, Delaware, United States
Georgia Cancer Center /ID# 201894
🇺🇸Atlanta, Georgia, United States
Goshen Center for Cancer Care /ID# 156682
🇺🇸Goshen, Indiana, United States
Nebraska Hematology Oncology /ID# 156534
🇺🇸Lincoln, Nebraska, United States
Cone Health /ID# 156689
🇺🇸Greensboro, North Carolina, United States
Royal North Shore Hospital /ID# 158881
🇦🇺Saint Leonards, New South Wales, Australia
Newcastle Private Hospital /ID# 203506
🇦🇺Lambton Heights, New South Wales, Australia
Sunshine Hospital /ID# 161700
🇦🇺St Albans, Victoria, Australia
Affinity Clinical Research Ser /ID# 158887
🇦🇺Nedlands, Australia
SMZ Baumgartner Höhe, Otto-Wagner-Spital und Pflegezentrum /ID# 201776
🇦🇹Vienna, Wien, Austria
Krankenhaus Nord - Klinik Floridsdorf /ID# 201768
🇦🇹Vienna, Wien, Austria
Ordensklinikum Linz GmbH, Elisabethinen /ID# 159564
🇦🇹Linz, Austria
Salzburger Landeskliniken (SALK) /ID# 201779
🇦🇹Salzburg, Austria
Bobruysk Interdistrict Onco. /ID# 169393
🇧🇾Bobruisk, Belarus
State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159383
🇧🇾Lesnoy, Belarus
Mogilev Reg Clin Oncology Dis /ID# 159384
🇧🇾Mogilev, Belarus
Grand Hôpital de Charleroi /ID# 159006
🇧🇪Charleroi, Hainaut, Belgium
CHU Saint-Pierre /ID# 159009
🇧🇪Bruxelles, Bruxelles-Capitale, Belgium
ZNA Middelheim /ID# 159007
🇧🇪Antwerp, Belgium
CHU Charleroi (Vesale) /ID# 159008
🇧🇪Montigny-le-tilleul, Belgium
Hospital Evangelico de Cachoei /ID# 159657
🇧🇷Cachoeiro de Itapemirim, Espirito Santo, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159012
🇧🇷Barretos, Sao Paulo, Brazil
UMHAT Tsaritsa Joanna - ISUL /ID# 159638
🇧🇬Sofia, Bulgaria
UMHAT Sv. Ivan Rilski /ID# 159639
🇧🇬Sofia, Bulgaria
Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159658
🇧🇷Rio de Janeiro, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159659
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
Princess Margaret /ID# 170868
🇨🇦Toronto, Ontario, Canada
Yunnan Cancer Hospital /ID# 204911
🇨🇳Kunming, Yunnan, China
Zhejiang Cancer hospital /ID# 204640
🇨🇳Hangzhou, Zhejiang, China
Jiangsu Province Hospital /ID# 205183
🇨🇳Nanjing, China
Henan Cancer Hospital /ID# 203983
🇨🇳Zhengzhou Henan, China
First Affiliated Hospital of Xi'an Jiaotong University /ID# 203733
🇨🇳Xi'an, China
Klinika za plucne bolesti Jordanovac /ID# 159505
🇭🇷Zagreb, Grad Zagreb, Croatia
Thomayerova nemocnice /ID# 159062
🇨🇿Prague, Praha 4, Czechia
North Estonian Medical Centre /ID# 159779
🇪🇪Tallinn, Estonia
Centre Leon Berard /ID# 160550
🇫🇷Lyon CEDEX 08, Rhone, France
Nouvel Hopital Civil (NHC) /ID# 204427
🇫🇷Strasbourg, France
Hospital Pontchaillou /ID# 160544
🇫🇷Rennes, France
Thoraxklinik Heidelberg gGmbH /ID# 158871
🇩🇪Heidelberg, Germany
Metropolitan Hospital /ID# 159157
🇬🇷Athens, Greece
University Hospital of Ioannin /ID# 159158
🇬🇷Ioannina, Greece
Rabin Medical Center /ID# 159764
🇮🇱Petakh Tikva, Tel-Aviv, Israel
Csongrad Megyei Mellkasi Beteg /ID# 158952
🇭🇺Deszk, Hungary
Semmelweis Egyetem /ID# 158955
🇭🇺Budapest, Hungary
Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz - Pulmonologia /ID# 202466
🇭🇺Nyiregyhaza, Szabolcs-Szatmar-Bereg, Hungary
University Hospital Limerick /ID# 159714
🇮🇪Limerick, Ireland
Aichi Cancer Center Hospital /ID# 164976
🇯🇵Nagoya-shi, Aichi, Japan
Kyushu University Hospital /ID# 165722
🇯🇵Fukuoka-shi, Fukuoka, Japan
National Cancer Center Hospital East /ID# 165721
🇯🇵Kashiwa-shi, Chiba, Japan
Kanagawa Cardiovascular and Respiratory Center /ID# 165015
🇯🇵Yokohama-shi, Kanagawa, Japan
Showa University Hospital /ID# 165575
🇯🇵Shinagawa-ku, Tokyo, Japan
Hyogo Cancer Center /ID# 165138
🇯🇵Akashi, Japan
CHA Bundang Medical center CHA University /ID# 161281
🇰🇷Seongnam si, Gyeonggido, Korea, Republic of
Kyungpook National University Chilgok Hospital /ID# 159301
🇰🇷Daegu, Seoul Teugbyeolsi, Korea, Republic of
Riga East Clinical University /ID# 158716
🇱🇻Riga, Latvia
Unidade Local Saude Matosinhos /ID# 159950
🇵🇹Matosinhos, Portugal
OOO Centre of Palliative Medicine De Vita /ID# 206855
🇷🇺Saint Petersburg, Russian Federation
Arkhangelsk clinical oncology /ID# 159367
🇷🇺Arkhangelsk, Russian Federation
PMI Euromedservice /ID# 159369
🇷🇺Pushkin, Russian Federation
Clinical Center of Nis /ID# 160905
🇷🇸NIS, Nisavski Okrug, Serbia
Hopitaux Universitaires de Geneve /ID# 160603
🇨🇭Genève, Geneve, Switzerland
Universitaetsspital Basel /ID# 160605
🇨🇭Basel, Switzerland
Luzerner Kantonsspital /ID# 160607
🇨🇭Luzern, Switzerland
Taipei Veterans General Hosp /ID# 203699
🇨🇳Taipei City, Taiwan
Istanbul Medeniyet Universites /ID# 200126
🇹🇷Istanbul, Turkey
Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 159864
🇺🇦Chernivtsi, Ukraine
The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 159044
🇬🇧Newcastle Upon Tyne, United Kingdom
West Virginia Univ School Med /ID# 156687
🇺🇸Morgantown, West Virginia, United States
Palo Alto Veterans Institute for Research /ID# 203695
🇺🇸Palo Alto, California, United States
Memorial Cancer Institute /ID# 164052
🇺🇸Hollywood, Florida, United States
Cancer Specialists of North Florida - Southpoint /ID# 156595
🇺🇸Jacksonville, Florida, United States
Cone Health /ID# 163612
🇺🇸Greensboro, North Carolina, United States
VA Pittsburgh HealthcareSystem /ID# 159284
🇺🇸Pittsburgh, Pennsylvania, United States
Rhode Island Hospital /ID# 160834
🇺🇸Providence, Rhode Island, United States
Sarah Cannon Research Institute-Chattanooga /ID# 202933
🇺🇸Chattanooga, Tennessee, United States
Thompson Cancer Survival Ctr /ID# 202460
🇺🇸Knoxville, Tennessee, United States
UT Southwestern Medical Center /ID# 157848
🇺🇸Dallas, Texas, United States
Medical Oncology Associates /ID# 156715
🇺🇸Spokane, Washington, United States
Coffs Harbour Hospital /ID# 158880
🇦🇺Coffs Harbour, New South Wales, Australia
Gosford Hospital /ID# 158884
🇦🇺Gosford, New South Wales, Australia
Calvary North Adelaide Hospita /ID# 161701
🇦🇺Adelaide, South Australia, Australia
Rambam Health Care Campus /ID# 202336
🇮🇱Haifa, Israel
Dong-A University Hospital /ID# 159305
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
Hospital Clinico Universitario Lozano Blesa /ID# 159709
🇪🇸Zaragoza, Spain
Holy Cross Hospital /ID# 156716
🇺🇸Fort Lauderdale, Florida, United States
Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159661
🇧🇷Passo Fundo, Rio Grande Do Sul, Brazil
Klinicki bolnicki centar Rijeka /ID# 159504
🇭🇷Rijeka, Primorsko-goranska Zupanija, Croatia
University of Louisville /ID# 156683
🇺🇸Louisville, Kentucky, United States
Mayo Clinic - Rochester /ID# 160181
🇺🇸Rochester, Minnesota, United States
MidAmerica Division, Inc. /ID# 163530
🇺🇸Kansas City, Missouri, United States
Univ Medical Ctr Brackenridge /ID# 155798
🇺🇸Austin, Texas, United States
University of Florida - Archer /ID# 155799
🇺🇸Gainesville, Florida, United States
Montefiore Medical Center /ID# 201845
🇺🇸Bronx, New York, United States
CHU Calmette /ID# 202706
🇫🇷Lille, Hauts-de-France, France
IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 160898
🇮🇹Meldola, Emilia-Romagna, Italy
Princess Margaret Hospital /ID# 162810
🇭🇰Lai Chi Kok, Hong Kong
Tuen Mun Hospital /ID# 162435
🇭🇰Tuen Mun, Hong Kong