Effect of transcranial direct current stimulation at the left dorsolateral prefrontal cortex (DLPFC) combined with quadriceps strengthening exercise in chronic knee osteoarthritis: A double blinded, randomised sham-controlled trial
- Conditions
- clinical pain severity in chronic knee osteoarthritis.Transcranial direct current stimulation, Chronic knee osteoarthritis, Dorsolateral prefrontal cortex, Pain
- Registration Number
- TCTR20210802001
- Lead Sponsor
- Faculty of Medicine, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 32
1. Age 50 - 90 years old
2.Diagnosed chronic knee osteoarthritis by American College of Rheumatology present with knee joint pain plus at least 3 of following
2.1Age more than 50 yr
2.2Morning stiffness more than 30 mins
2.3Crepitus
2.4Bony enlargement
2.5Bony tenderness
2.6No palpable warmth
3.Clinical knee pain by VAS 40-70 mm
4.Kellgren and Lawrence classification system grading 1 - 3
5.Knee pain at least 3 mo.
6.Can sit with support more than 20 mins
7.Not participate in others trial
8.Willing to participate by themselves
1.Hemodynamic or Neurological condition not stable
2.Cannot communicate or follow command
3.Acute inflammation on studied side
4.Knee joint replacement on studied side
5.History of intraarticular injection at studied side: steroid within 3 months and hyaluronic acid within 6 month
6.Have to had pain killer such as NSIADs within 2 weeks
7.History of MDD
8.History of non-invasive brain stimulation such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS)
9.Contraindications to tDCS
9.1Skin pathology, infection, wound, vasculitis at stimulate site
9.2History of bleeding tendency
9.3History of seizure or in family
9.4History of migraine
9.5History of brain surgery
9.6History of traumatic brain injury which alteration of conscious more than 15 min
9.7Neurodeficit
9.8Implanted metal device: pacemaker, metal plate, wires
9.9Pregnancy
9.10History adverse effect from other brain stimulation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pain severity Before and after intervention, past 4 wk after intervention Visual analogue scale (mm)
- Secondary Outcome Measures
Name Time Method Physical function Before and after intervention, past 4 wk after intervention WOMAC score (questionaire),Pressure pain threshold Before and after intervention, past 4 wk after intervention digital algometer (kPa)),Quality of life Before and after intervention, past 4 wk after intervention The Short Form Health Survey-36 questionaire