Exercise and Repetitive Diving

Not Applicable

Completed

• Conditions: Neutrophil Activation; Venous Gas Emboli; Decompression Sickness; Endothelial Dysfunction
• Interventions: Other: Aerobic running exercise

• Registration Number: NCT02118207
• Lead Sponsor: University Hospital of Split

Brief Summary

SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.

16 divers in 2 groups each completed 6 dives. One group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. The other group completed the opposite protocol. Flow-mediated dilation (FMD) data and blood for MP analysis was collected before and after each dive. VGE were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. Exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% VO2max effort.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2013-11
• Study Completion: 2014-01
• Status Verified: 2014-04
• Study First Submitted: 2014-04-16
• Study First Submitted QC: 2014-04-16
• Last Update Submitted: 2014-04-16
• Study First Posted: 2014-04-21
• Last Update Posted: 2014-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Certified SCUBA diver
• Certified to dive by experienced Medical evaluator
• Must be able to run continuously for 45 min

Exclusion Criteria

• Prior diagnosis of decompression sickness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control dives 1st	Aerobic running exercise	Subjects in this group complete the first 3 dives as control dives and the second 3 dives preceded by aerobic exercise
Predive exercise 1st	Aerobic running exercise	Subjects complete the first 3 dives preceded by the intervention of aerobic exercise and the second 3 with no exercise as control dives

Primary Outcome Measures

Name	Time	Method
Change in circulating microparticle counts	2 weeks	Change in circulating microparticle counts measured pre and post SCUBA diving following 6 dives spaced over 12 days

Trial Locations

Locations (2)

University of Split School of Medicine; 🇭🇷 Split, Croatia

University of Maryland; 🇺🇸 Baltimore, Maryland, United States