Predictive Ability of Therapeutic Risk Factors in Pediatric and Adult Asthma Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101,437
- 主要终点
- Mean Ratio of Controller Medication to Total Asthma Medication
研究概览
简要总结
The purpose of this study is to assess the predictive ability of three asthma risk markers: the ratio of controller medication to total asthma medication, an albuterol only marker, and an oral corticosteroid use marker, as well as to compare the precision of these tools between adult and pediatric patient populations. This retrospective longitudinal analysis will use 2 different databases: a large managed care database and a large fee for service Medicaid database.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 4 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with asthma as determined by ICD-9 codes and asthma drug use
- •at least 4 years of age
- •use of at least 1 controller or at least 5 albuterol prescriptions in 12 months
排除标准
- •Subjects with COPD or treatment for COPD
研究组 & 干预措施
Pediatric participants
Pediatric participants (age 4 to 17) with a diagnosis of asthma
干预措施: Asthma treatment with an asthma-related medication and at least one asthma controller medication (Drug)
Adult participants
Adult participants (age 18 and older) with a diagnosis of asthma
干预措施: Asthma treatment with an asthma-related medication and at least one asthma controller medication (Drug)
结局指标
主要结局
Mean Ratio of Controller Medication to Total Asthma Medication
时间窗: January 1, 2004 to June 30, 2006: 3, 6, and 12 month follow-up periods
The ratio of controller medication (CM) to total asthma medication (AM), which is well established in predicting future asthma events in adults, was calculated as the ratio of the units of CMs used during the defined period divided by the sum of the units of CMs plus the units of inhaled short-acting beta-agonists used during the same period. A CM is defined as any inhaled corticosteroid containing medication, methylxanthines, leukotriene receptor antagonists, or cromolyn sodium. The ratio is calculated using all CM. Asthma controllers are medications used to treat asthma on a regular basis.
次要结局
- Mean Number of Short-acting Beta-agonist (SABA) Canisters Used(January 1, 2004 to June 30, 2006: 3, 6, and 12 month follow-up periods)