The effects of fluid loading on cardiac response and acid-base status in the critically ill

Completed

• Conditions: Clinically hypovolemic critically ill patients; Circulatory System; Hypovolemia

• Registration Number: ISRCTN19023197
• Lead Sponsor: Vrije Universiteit Medical Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-26
• Last Update Posted: 8 May 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

Participant inclusion criteria as of 24/02/2016:
1. Clinically presumed hypovolaemic critically ill patients, defined as a pulmonary capillary wedge pressure (PCWP) below 10 mmHg in the presence of a pulmonary artery catheter and proper wedging or a central venous pressure (CVP) below 8 mmHg at positive end-expiratory pressure (PEEP) =15 cm H2O and below 12 mm Hg when PEEP >15 cm H2O in the presence of a central venous catheter, and a systolic arterial pressure <110 mmHg in the absence of vasopressor therapy.
2. The presence of a pulmonary artery or central venous catheter.

Original participant inclusion criteria:
1. Clinically presumed hypovolaemia
2. Presence of a pulmonary artery or central venous catheter

Exclusion Criteria

1. Age >78 years
2. Pregnancy
3. Known anaphylactoid reactions to colloids
4. A life expectancy ofless than 24 h.

Study & Design

• Study Type: Interventional
• Study Design: Not specified