An open label randomized comparative clinical study to evaluate the efficacy of Bahumutrantaka Rasa and Chandrakala Vati in Madhumeha vis-a-vis Type 2 Diabetes Mellitus

Prameha is characterized by *‘Prabhuta’*and â€˜Avila’ Mootrata. Madhumeha is a type of Vataja Prameha, characterized by the passage of excessive urine having quality similar to Madhu. It is one among the Astamahagada.

Type 2 Diabetes Mellitus is a heterogeneous condition characterized by varying degrees of Insulin resistance and β-cell dysfunction. It is one of the lifestyle disorders whose prevalence is rising more rapidly in almost all countries.

In the present scenario, Santarpanajanya Vikaras are given much importance as it is a very common set of disorders. A sedentary lifestyle such as lack of exercise, sleeping during the daytime, consumption of excessive sweets and oily food, change in dietary habits precipitate the Santarpanajanya Vikaras such as Prameha.

India is topped in the world with the highest number of people with Diabetes Mellitus. India has around 101 million people living with Diabetes and another 136 million people in Pre-Diabetes stages.About 422 million people worldwide have Diabetes. Diabetes Mellitus is fast-growing public health challenge of the 21st century as the prevalence rate will be >30% in the next 35 years. India is gaining the status of a potential epidemic with >62 million Diabetic individuals and is expected to double this number by the year 2040.

Management of T2DM encompasses lifestyle adjustments, medications and in certain instances insulin therapy. Pharmacotherapy includes a range of oral hypoglycemic drugs. Despite the considerable advancements made in the control of T2DM, there are still problems that persist. These challenges encompass the requirement of treatment strategies, for the mitigation of medication-related adverse effects, mitigation of complications associated with the condition, potential for enhancing positive outcomes in T2DM subjects.

Medicines used in the study, Bahumutrantaka Rasa and Chandrakala Vati being herbomineral formulations have Mehahara property, their efficacies are evaluated and compared in the subjects diagnosed with Madhumeha vis-à-vis Type 2 Diabetes Mellitus.