NCT03034629已完成不适用
Assessing the Reliability and Influence of Timing of Exercise on Transcranial Magnetic Stimulation (TMS) Neuroplasticity Measures
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Change in cortical synaptic plasticity
研究概览
简要总结
The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult males and females aged 18-70 years old.
- •Primary language is English
- •Exercise clearance
排除标准
- •Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
- •History of migraines
- •History of fainting spells of unknown or undetermined etiology that might constitute seizures
- •History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy
- •Any current history of psychiatric illness
- •Any unstable medical condition
- •No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
- •The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs.
- •The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009)
- •Any metal in the brain, skull or elsewhere unless approved by the responsible MD
- •Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
- •Intracranial lesion
- •Substance abuse or dependence within the past six months
结局指标
主要结局
Change in cortical synaptic plasticity
时间窗: Baseline, 1 week
As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude
次要结局
- Assess TMS plasticity measures on healthy individuals after an acute bout of exercise(Baseline, 3 weeks)
研究者
Joyce Rios Gomes Osman
Assistant Professor
University of Miami
研究点 (2)
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