Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Short-term aerobic exercise

• Registration Number: NCT03034629
• Lead Sponsor: University of Miami

Brief Summary

The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-01-16
• Study First Submitted QC: 2017-01-24
• Study First Posted: 2017-01-27
• Study Start: 2017-05-22
• Primary Completion: 2021-03-03
• Study Completion: 2021-09-27
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-24
• Last Update Posted: 2021-12-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Adult males and females aged 18-70 years old.
• Primary language is English
• Exercise clearance

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Exclusion Criteria

• Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
• History of migraines
• History of fainting spells of unknown or undetermined etiology that might constitute seizures
• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy
• Any current history of psychiatric illness
• Any unstable medical condition
• No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
• The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs.
• The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009)
• Any metal in the brain, skull or elsewhere unless approved by the responsible MD
• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
• Intracranial lesion
• Substance abuse or dependence within the past six months

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Short-term aerobic exercise	Short-term aerobic exercise	One bout of moderate intensity exercise (75% of maximal predicated heart rate).

Primary Outcome Measures

Name	Time	Method
Change in cortical synaptic plasticity	Baseline, 1 week	As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude

Secondary Outcome Measures

Name	Time	Method
Assess TMS plasticity measures on healthy individuals after an acute bout of exercise	Baseline, 3 weeks	As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude after an acute bout of aerobic exercise

Trial Locations

Locations (1)

University of Miami Miller School of Medicine; 🇺🇸 Miami, Florida, United States