Perthes Disease in Norway

Active, not recruiting

• Conditions: Legg Calve Perthes Disease

• Registration Number: NCT03885960
• Lead Sponsor: Oslo University Hospital

Brief Summary

Calvé-Legg-Perthes disease (CLP) is a hip disease in children whose femoral head becomes completely or partially necrotic. The disease is most common in five-six years of age. The femoral head is gradually deformed during the active stages of the disease (5-7 years). By healing, the hip joint shape will vary from an approximately normal joint to pronounced changes, the hip joint will be irregular. Such a hip joint is available for osteoarthritis. The purpose of this study is to map the function of the hip, the patient's quality of life and especially the risk factors that affect the outcome of the previous CLP. A nationwide prospective study of CLP was conducted between 1996 and 2000. All children with newly diagnosed Perthes disease (425) were registered. The current study will follow up all these patients with an average follow-up of 20 years. Radiological endpoints are evidence of hip osteoarthritis. Patient-reported outcomes (PROMS) should illuminate the function of the hip and quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-01
• Study First Submitted: 2019-01-09
• Study First Submitted QC: 2019-03-21
• Study First Posted: 2019-03-22
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-17
• Last Update Posted: 2025-03-18
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 216

Inclusion Criteria

Not provided

Exclusion Criteria

• Death upon follow up
• Other skeletal dysplasia
• Patient not able to give consent,

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hip osteoarthritis	an average of 20 years follow-up	radiographic measurement of weight bearing zone
Hip function	an average of 20 years follow-up	PROMS HOOS

Secondary Outcome Measures

Name	Time	Method
Hip ROM	an average of 20 years follow-up	functional test of range of motion of the hip
Gluteal muscle strength	an average of 20 years follow-up	Trendelenburg test
Hip strength	an average of 20 years follow-up	single leg hop test - 6 meters

Trial Locations

Locations (1)

Oslo University Hospital - Rikshospitalet; 🇳🇴 Oslo, Sognsvannsveien 20, Norway