The Effects of the Female Sex Hormones and Hormonal Contraception on Cerebral Perfusion
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebral Perfusion
- Sponsor
- University Ghent
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Regional cerebral perfusion (ml/100g/min): natural versus contraception
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Bachelor or Master student
- •Minimum of 3 months not using contraception of using Deso20
Exclusion Criteria
- •No informed consent
- •MRI-contraindications
- •Claustrophobia
- •Pregnancy or breastfeeding
- •Chronic diseases and chronic medication use
- •Abuse of alcohol and caffeine
Outcomes
Primary Outcomes
Regional cerebral perfusion (ml/100g/min): natural versus contraception
Time Frame: measured during scan-session
Differences in regional perfusion between volunteers of the natural cycle group versus the volunteers using contraception
Regional cerebral perfusion (ml/100g/min) variations during natural menstrual cycle
Time Frame: measured during scan-session
Variations in cerebral perfusion during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample
Regional cerebral perfusion (ml/100g/min) variations during menstrual cycle using contraception
Time Frame: measured during scan-session
Variations in cerebral perfusion during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample
Secondary Outcomes
- Regional grey matter volume (mm³): natural versus contraception(measured during scan-session)
- Resting state brain activity variations during natural menstrual cycle(measured during scan-session)
- Resting state brain activity: natural versus contraception(measured during scan-session)
- Cerebral diffusion properties: natural versus contraception(measured during scan-session)
- Cerebral diffusion properties variations during menstrual cycle using contraception(measured during scan-session)
- Resting state brain activity variations during menstrual cycle using contraception(measured during scan-session)
- Regional grey matter volume (mm³) variations during natural menstrual cycle(measured during scan-session)
- Regional grey matter volume (mm³) variations during menstrual cycle using contraception(measured during scan-session)
- Cerebral diffusion properties variations during natural menstrual cycle(measured during scan-session)