The Effects of the Female Sex Hormones and Hormonal Contraception on Cerebral Perfusion
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Regional cerebral perfusion (ml/100g/min): natural versus contraception
研究概览
简要总结
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Bachelor or Master student
- •Minimum of 3 months not using contraception of using Deso20
排除标准
- •No informed consent
- •MRI-contraindications
- •Claustrophobia
- •Pregnancy or breastfeeding
- •Chronic diseases and chronic medication use
- •Abuse of alcohol and caffeine
结局指标
主要结局
Regional cerebral perfusion (ml/100g/min): natural versus contraception
时间窗: measured during scan-session
Differences in regional perfusion between volunteers of the natural cycle group versus the volunteers using contraception
Regional cerebral perfusion (ml/100g/min) variations during natural menstrual cycle
时间窗: measured during scan-session
Variations in cerebral perfusion during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample
Regional cerebral perfusion (ml/100g/min) variations during menstrual cycle using contraception
时间窗: measured during scan-session
Variations in cerebral perfusion during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample
次要结局
- Regional grey matter volume (mm³): natural versus contraception(measured during scan-session)
- Resting state brain activity variations during natural menstrual cycle(measured during scan-session)
- Resting state brain activity: natural versus contraception(measured during scan-session)
- Cerebral diffusion properties: natural versus contraception(measured during scan-session)
- Cerebral diffusion properties variations during menstrual cycle using contraception(measured during scan-session)
- Resting state brain activity variations during menstrual cycle using contraception(measured during scan-session)
- Regional grey matter volume (mm³) variations during natural menstrual cycle(measured during scan-session)
- Regional grey matter volume (mm³) variations during menstrual cycle using contraception(measured during scan-session)
- Cerebral diffusion properties variations during natural menstrual cycle(measured during scan-session)