The Effects of Mood on Cerebral Perfusion

Not Applicable

Completed

• Conditions: Cerebral Perfusion
• Interventions: Behavioral: Mood induction (using own memories); Device: Arterial spin labeling MRI; Device: Physiological monitoring

• Registration Number: NCT03302130
• Lead Sponsor: University Ghent

Brief Summary

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-08
• Study First Submitted: 2016-10-06
• Study First Submitted QC: 2017-09-29
• Study First Posted: 2017-10-04
• Primary Completion: 2017-10-30
• Study Completion: 2017-11-17
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-08
• Last Update Posted: 2022-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Healthy university students
• between 18 and 30 years old

Exclusion Criteria

• No informed consent
• Not using hormonal contraception
• MRI-contraindications
• Claustrophobia
• Pregnancy
• Chronic diseases and chronic medication use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Imaging healthy volunteers	Arterial spin labeling MRI	Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring
Imaging healthy volunteers	Physiological monitoring	Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring
Imaging healthy volunteers	Mood induction (using own memories)	Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring

Primary Outcome Measures

Name	Time	Method
Regional Cerebral perfusion (ml/100g/min) during positive mood induction	2 minutes (ASL scan during mood state induction)	Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) during negative mood induction	2 minutes (ASL scan during mood state induction)	Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) during neutral mood induction	2 minutes (ASL scan during mood state induction)	Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) after positive mood induction	2 minutes (ASL scan after mood state induction)	Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) after negative mood induction	2 minutes (ASL scan after mood state induction)	Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) after neutral mood induction	2 minutes (ASL scan after mood state induction)	Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.