Comparison of Clinical Results of Frozen Embryo Transfer in Natural and Modified Natural Cycles
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- birth
研究概览
简要总结
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer
详细描述
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that:
- The endometrium in stimulated cycles is not optimal for implantation
- Pregnancy rates are increased following FET
- Perinatal outcomes are less affected after FET
- Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter.
We will compare success rate between natural and modified natural cycles
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patient who are admitted to the IVF center and who will be transferred to frozen embryos.
- •Infertile women under 40 years of age who accepted this study.
- •Unexplained infertilite couple.
- •All ovulatory patient.
- •Male factor.
- •Tubal factor.
排除标准
- •Patients who made intrauterin surgery.
- •Over 40 years of age women.
- •Patients with preimplantation genetic diagnosis.
- •Anovulatory patient.
结局指标
主要结局
birth
时间窗: bigger than 24 weeks pregnancy
live birth
次要结局
- pregnancy rate(10th day after embryo transfer)
- abortion rate(8 weeks)
- clinical pregnancy rate(8 weeks)