NCT02201121已完成不适用
Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation
Chinese PLA General Hospital0 个研究点目标入组 94 人开始时间: 2014年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 94
- 主要终点
- invasive arterial blood pressure as a Measure of Safety
研究概览
简要总结
Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.
详细描述
Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
- •Body mass index (BMI) ranged from 18 to 26
- •None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
- •All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection
排除标准
- •Persistent arrhythmias
- •Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine
结局指标
主要结局
invasive arterial blood pressure as a Measure of Safety
时间窗: DAY 1
if instability of circulation, stop the clinical trial
次要结局
未报告次要终点
研究者
Ran Kong
Department of Anesthesiology, People's Liberation Army General Hospital, Beijing, China
Chinese PLA General Hospital
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