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临床试验/NCT04897620
NCT04897620Unknown不适用

COMPARISON OF SYSTEMIC INFLAMMATION-RELATED HEMATOLOGICAL PARAMETERS IN ACUTE AND CHRONIC LOW BACK PAIN

Ufuk University1 个研究点 分布在 1 个国家目标入组 450 人开始时间: 2021年5月5日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
450
试验地点
1
主要终点
Red blood cell distribution width

研究概览

简要总结

The aim of the study is to compare the neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR), eosinophils to lymphocytes ratio (ELR), red blood cell distribution width (RDW), mean platelet volume (MPV), systemic immune inflammation index (SII), erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) which are the hematological parameters associated with systemic inflammation in acute and subacute/chronic low back pain. Secondary purpose; evaluation of the prognostic roles of hematological parameters associated with systemic inflammation in low back pain in predicting chronicity.This study is a retrospective case-control study. The data of patients who applied to the emergency department with the complaint of acute (less than 4 weeks) low back pain or to the Physical Medicine and Rehabilitation outpatient clinic with the complaint of subacute (lasting 4-12 weeks) or chronic (longer than 12 weeks) non-specific low back pain in the last 3 years will be scanned. The data of patients who applied with complaints other than medical conditions known to be associated with painful conditions and/or inflammatory response will be screened as a control group. The data of patients between the ages of 18-65 will be included in the study. In conclusion, the data of 150 patients who presented with acute non-specific low back pain, 150 patients who presented with subacute/chronic non-specific low back pain and 150 participants as the control group will be included in the study for use in analysis. Participants' age, gender, duration of low back pain (days), if evaluated, conditions associated with low back pain in cases with subacute/chronic pain, ESR, CRP, RDW, MPV, neutrophil count, lymphocyte count, eosinophil count and platelet count in blood tests at admission examinations will be recorded. NLR will be calculated by dividing the number of neutrophils by the number of lymphocytes, PLR by dividing the number of platelets by the number of lymphocytes, ELR by dividing the number of eosinophils by the number of lymphocytes, and SII by the formula "platelet numberxneutrophil number/lymphocyte number".

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • The data of patients who applied to the emergency department with the complaint of acute (less than 4 weeks) low back pain or to the Physical Medicine and Rehabilitation outpatient clinic with the complaint of subacute (lasting 4-12 weeks) or chronic (longer than 12 weeks) non-specific low back pain in the last 3 years.
  • The data of patients between the ages of 18-65.

排除标准

  • Patients who have systemic diseases or internal organ pathologies that may cause low back pain, acute/chronic infection, malignancy, rheumatic disease or systemic diseases that may change the hematological inflammation parameters, which are evaluation parameters,
  • Patients who have severe neurological involvement findings in imaging examinations or clinical examination,
  • Patients who have a history of surgical procedures for the lumbar region in the last 6 months
  • Patients those missing one or more of the parameters planned to be evaluated within the scope of the screened data.

结局指标

主要结局

Red blood cell distribution width

时间窗: 1 month

The red blood cell distribution width value in blood tests at admission examinations.

Neutrophils to lymphocytes ratio (NLR)

时间窗: 1 month

NLR is calculated by dividing the number of neutrophils by the number of lymphocytes.

Platelets to lymphocytes ratio (PLR)

时间窗: 1 month

PLR is calculated by dividing the number of platelets by the number of lymphocytes.

Erythrocyte sedimentation rate

时间窗: 1 month

The erythrocyte sedimentation rate value in blood tests at admission examinations.

C reactive protein

时间窗: 1 month

The C reactive protein value in blood tests at admission examinations.

Mean platelet volume

时间窗: 1 month

The mean platelet volume value in blood tests at admission examinations.

Eosinophils to lymphocytes ratio (ELR)

时间窗: 1 month

ELR is calculated by dividing the number of eosinophils by the number of lymphocytes.

Systemic immune inflammation index (SII)

时间窗: 1 month

SII is calculated by the formula "platelet numberxneutrophil number/lymphocyte number.

次要结局

未报告次要终点

研究者

发起方
Ufuk University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Elzem Bolkan Günaydın

Lecturer Doctor

Ufuk University

研究点 (1)

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