Infantile Hemangioma With Minimal or Arrested Growth : Epidemiology, Clinical Characteristics and Evolution

Completed

• Conditions: Hemangioma, Capillary

• Registration Number: NCT05080868
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Infantile hemangioma (IH) is the most common vascular tumor of infancy, characterized by its clinical history. Absent at birth or present under the form of a premonitory mark, they display a rapid proliferative phase starting in the first weeks of life. Then, after a plateau phase, they slowly involute. However, a subtype of IH named "abortive", "minimal or arrested growth", "reticular" or "telangiectatic" hemangioma differs from typical IH because it doesn't have a proliferative component, or only a minimal one. This subtype of hemangioma has been recently described and data are lacking regarding its proportion among infantile hemangioma and its differences with "classic" infantile hemangioma. The aim of this study is to estimate the proportion of abortive hemangioma among infantile hemangioma. Also, the investigators aim to compare the clinical characteristics of "classic" infantile hemangiomas and abortive hemangiomas. Lastly, investigators wished to study the evolution of abortive hemangioma.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-12
• Study Start: 2021-03-23
• Primary Completion: 2021-05-30
• Study Completion: 2021-08-15
• Status Verified: 2021-10
• Study First Submitted QC: 2021-10-04
• Last Update Submitted: 2021-10-04
• Study First Posted: 2021-10-18
• Last Update Posted: 2021-10-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

• Children between 0 and 18 years old
• Followed in the dermatology department of CHRU de Nancy between January 2014 and December 2020
• Presenting with one or more infantile hemangioma

Exclusion Criteria

• Those whoes guardian does not want his data to be collected in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of abortive hemangioma among infantile hemangioma	baseline	Proportion of abortive hemangioma among infantile hemangioma

Secondary Outcome Measures

Name	Time	Method
To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : prematurity	baseline	Compare prematurity rates between infantile hemangiomas and abortive hemangiomas
To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : birthweight	baseline	Compare birthweight between infantile hemangiomas and abortive hemangiomas
To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : localization	baseline	Compare localization between infantile hemangiomas and abortive hemangiomas
To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : treatment	baseline	le hemangiomas and abortive hemangiomaCompare treatment between infanti
To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : complications	baseline	Compare complications between infantile hemangiomas and abortive hemangioma
To compare the epidemiological characteristics between infantile hemangioma and abortive hemangioma : sex	baseline	Compare sex predominance between infantile hemangioma and abortive hemangioma
To study the evolution of abortive hemangioma : telangiectasias	through study completion, an average of 4 years	Evaluation of the fading of telangiectasias between the stage of maximal proliferation and the last follow-up
To study the evolution of abortive hemangioma : halo of vasoconstriction	through study completion, an average of 4 years	Evaluation of the fading of the vasoconstricted halo between the stage of maximal proliferation and the last follow-up
To study the evolution of abortive hemangioma : dilated veins	through study completion, an average of 4 years	Evaluation of the fading of dilated veins between the stage of maximal proliferation and the last follow-up
To study the evolution of abortive hemangioma : areas of vasoconstriction	through study completion, an average of 4 years	Evaluation of the fading of vasoconstricted areas between the stage of maximal proliferation and the last follow-up
To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : size	baseline	Compare size (focal, extended or segmental) between infantile hemangiomas and abortive hemangioma
To study the evolution of abortive hemangioma : erythematous macule	through study completion, an average of 4 years	Evaluation of the fading of erythematous macule between the stage of maximal proliferation and the last follow-up
To study the evolution of abortive hemangioma : papules of proliferation	through study completion, an average of 4 years	Evaluation of the regression of the papules of proliferation between the stage of maximal proliferation and the last follow-up

Trial Locations

Locations (1)

CHRU de Nancy; 🇫🇷 Nancy, Grand-Est, France