The effect of antihypertensive treatment with Lisinopril and Labetalol on baroreflex sensitivity in stroke

Completed

• Conditions: Cardiovascular: Stroke; Circulatory System; Stroke

• Registration Number: ISRCTN37578410
• Lead Sponsor: Record Provided by the NHSTCT Register - 2005 Update - Department of Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-19
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

Patients with previous stroke or transient ischaemic attack (TIA).
1. Age > 18 years

2. Clinical diagnosis of stroke > 8 weeks ago
3. Stable neurology
4. Clinical indication for antihypertensive treatment
5. Informed consent

Exclusion Criteria

1. Excessive ectopic activity
2. Atrial fibrillation
3. Contraindication to beta blocker therapy
4. Contraindication to ace inhibitor therapy
5. Clinical indication for treatment with ace inhibitor, beta blocker or angiotesin II antagonist other than hypertension
6. Conditions independently associated with autoimmune dysfunction (acute myocardial infarction, unstable angina, active heart failure, diabetes mellitus)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in BRS seen as a result of treatment with lisinopril and labetalol.

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration