Assessment of Antimicrobial Efficacy of Nano Chitosan, Chlorhexidine, Chlorhexidine/ Nano Chitosan Combination Versus Sodium Hypochlorite Irrigation in Patients With Necrotic Mandibular Posterior Teeth: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number of Colony Forming Units Per Millilitre
研究概览
简要总结
proper disinfection of root canal system before obturation is a must for long term success of endodontic treatment, therefore a proper irrigant is mandatory, therefore investigators are studying the antibacterial effects of 4 different irrgating solutions in root canal treatment of patients diagnosed with necrotic pulps in their mandibular posterior teeth. patients will be recruited from outpatient clinic of the endodontic department in cairo university. endodontic treatment will be carried out as usual and samples from the infected root canals will be collected before and after preparation to be cultivated and analyzed at the laboratories of microbiology of faculty of medicine, cairo university
详细描述
Title:
Assessment of Antimicrobial Efficacy of Nano Chitosan, Chlorhexidine, Chlorhexidine/ Nano Chitosan Combination versus Sodium Hypochlorite Irrigation in Patients with Necrotic Mandibular Posterior Teeth: A Randomized Clinical Trial
Introduction
• Background
Bacteria play a major role in the pathogenesis of apical periodontitis; therefore, success of endodontic treatment is dependent on its complete eradication before obturation1.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 22 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient's age between 22-45 years.
- •Both male and female.
- •Patient who are medically free and with good health
- •Necrotic Mandibular posterior teeth
排除标准
- •Pregnant females.
- •Teeth with vital inflamed pulps, symptomatic periapical abscess and facial cellulitis, periodontally diseased and hopeless teeth.
- •Teeth with previous fillings and/ or previous endodontic treatment
研究组 & 干预措施
Chitosan NPs group
irrigation with Chitosan nanoparticles (final flush)
干预措施: irrigation (Procedure)
Chlorhexidine group
irrigation with CHX (final flush)
干预措施: irrigation (Procedure)
Combination group
irrigation with CHX/ nano Chitosan combination (final flush)
干预措施: irrigation (Procedure)
Hypochlorite group
irrigation with NaOCL (final flush)
干预措施: irrigation (Procedure)
结局指标
主要结局
Number of Colony Forming Units Per Millilitre
时间窗: 1 week after culture
activity of the irrigating solution against bacteria in the root canal system, the less the number of colony forming units the better the irrigating solution is
次要结局
- Numerical Rating Scale(after 6 hours,12 hours, 24 hours, 48 hours, 72 hours and 7 days postoperatively)
研究者
Maha Nasr
assistant lecturer of Endodontics
Cairo University