High-flux Hemodialysis Versus Hemodiafiltration for End-Stage Renal Disease

Not Applicable

• Conditions: Chronic Kidney Failure

• Registration Number: NCT03456232
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

This study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on small and moderate molecule substances clearance. Meanwhile, this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on cardiac function. In this self matching study, participants will receive high-flux hemodialysis compared to hemodiafiltration.

Detailed Description

Hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water, is one of the most commonly replacement therapy.

Hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.

Study Timeline

• Study Start: 2017-12-21
• Status Verified: 2018-02
• Study First Submitted: 2018-02-27
• Study First Submitted QC: 2018-03-05
• Last Update Submitted: 2018-03-05
• Study First Posted: 2018-03-07
• Last Update Posted: 2018-03-07
• Primary Completion: 2018-03-10
• Study Completion: 2018-03-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Subject has end-stage renal disease.
2. Subject has been on regular dialysis treatment for at least 6 months.
3. Subject has autologous vascular access.
4. Subject is offered thrice weekly hemodialysis.
5. Subject is offered 4 hours duration hemodialysis.

Exclusion Criteria

1. Infectious disease
2. Poor echocardiographic window that was unsuitable for interpretation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Clearance of moderate molecule substance	4 hours after dialysis	Clearance rate of b2-microglobulin for one dialysis.

Secondary Outcome Measures

Name	Time	Method
Left ventricular ejection fraction	4 hours after dialysis	Left ventricular ejection fraction is calculated by dividing the volume of blood pumped from the left ventricle per beat, also known as stroke volume, by the end-diastolic volume.

Trial Locations

Locations (1)

Guangdong General Hospital; 🇨🇳 Guangzhou, Guangdong, China