High-flux Hemodialysis Versus Hemodiafiltration for End-Stage Renal Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Clearance of moderate molecule substance
研究概览
简要总结
This study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on small and moderate molecule substances clearance. Meanwhile, this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on cardiac function. In this self matching study, participants will receive high-flux hemodialysis compared to hemodiafiltration.
详细描述
Hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water, is one of the most commonly replacement therapy.
Hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject has end-stage renal disease.
- •Subject has been on regular dialysis treatment for at least 6 months.
- •Subject has autologous vascular access.
- •Subject is offered thrice weekly hemodialysis.
- •Subject is offered 4 hours duration hemodialysis.
排除标准
- •Infectious disease
- •Poor echocardiographic window that was unsuitable for interpretation
研究组 & 干预措施
High-flux hemodialysis
High-flux hemodialysis lasting for 4 hours
干预措施: High-flux hemodialysis (Other)
Hemodiafiltration
Hemodiafiltration lasting for 4 hours
干预措施: Hemodiafiltration (Other)
结局指标
主要结局
Clearance of moderate molecule substance
时间窗: 4 hours after dialysis
Clearance rate of b2-microglobulin for one dialysis.
次要结局
- Left ventricular ejection fraction(4 hours after dialysis)