The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care
- Conditions
- Renal Failure, Acute
- Registration Number
- NCT01403220
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 163
- According to RIFLE score, patient is stage 'F'
- The patient must be insured or beneficiary of a health insurance plan
- The patient meets at least one of the following criteria:
- metabolic acidosis (pH < 7.2), excluding keto-acidosis
- plasma urea > 25 mmol/l
- hyper-hydration is not controlled by diuretics
- Chronic, terminal renal insufficiency with dialysis
- The patient is under judicial protection, under tutorship or curatorship
- Suspect hyperkaliemia (Kaliemia > 6.5 mmol/l with electrocardiographic effects)
- Intoxications treated via dialysis
- Pregnant, lactating, parturient women
- Medical indication for localized citrate anticoagulation
- dialysis of less than 12 h
- patient or representative refuses to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%. 12 hours Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.
- Secondary Outcome Measures
Name Time Method Filter lifespan (hours) for the dialysis sequence under study. 12 hours. Filter lifespan (hours) for the dialysis sequence under study.
Fluid replacement (yes/no) 24 hours Was fluid replacement necessary during the studied dialysis sequence?
Urea clearance (ml/min) for the dialysis sequence under study 12 hours Urea clearance (ml/min) for the dialysis sequence under study.
Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%. 24 hours Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.
The percentage down-time for the first 24 hours of dialysis 24 hours The percentage down-time for the first 24 hours of dialysis = (number of hours where the exchange is not effective / 24 hours)\*100
Trial Locations
- Locations (1)
Centre Hospitalier Universitaire de Nîmes
🇫🇷Nîmes Cedex 09, Gard, France
Centre Hospitalier Universitaire de Nîmes🇫🇷Nîmes Cedex 09, Gard, France