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The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care

Not Applicable
Completed
Conditions
Renal Failure, Acute
Registration Number
NCT01403220
Lead Sponsor
Centre Hospitalier Universitaire de Nīmes
Brief Summary

The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
163
Inclusion Criteria
  • According to RIFLE score, patient is stage 'F'
  • The patient must be insured or beneficiary of a health insurance plan
  • The patient meets at least one of the following criteria:
  • metabolic acidosis (pH < 7.2), excluding keto-acidosis
  • plasma urea > 25 mmol/l
  • hyper-hydration is not controlled by diuretics
Exclusion Criteria
  • Chronic, terminal renal insufficiency with dialysis
  • The patient is under judicial protection, under tutorship or curatorship
  • Suspect hyperkaliemia (Kaliemia > 6.5 mmol/l with electrocardiographic effects)
  • Intoxications treated via dialysis
  • Pregnant, lactating, parturient women
  • Medical indication for localized citrate anticoagulation
  • dialysis of less than 12 h
  • patient or representative refuses to participate

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.12 hours

Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.

Secondary Outcome Measures
NameTimeMethod
Filter lifespan (hours) for the dialysis sequence under study.12 hours.

Filter lifespan (hours) for the dialysis sequence under study.

Fluid replacement (yes/no)24 hours

Was fluid replacement necessary during the studied dialysis sequence?

Urea clearance (ml/min) for the dialysis sequence under study12 hours

Urea clearance (ml/min) for the dialysis sequence under study.

Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.24 hours

Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.

The percentage down-time for the first 24 hours of dialysis24 hours

The percentage down-time for the first 24 hours of dialysis = (number of hours where the exchange is not effective / 24 hours)\*100

Trial Locations

Locations (1)

Centre Hospitalier Universitaire de Nîmes

🇫🇷

Nîmes Cedex 09, Gard, France

Centre Hospitalier Universitaire de Nîmes
🇫🇷Nîmes Cedex 09, Gard, France

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