Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients
Not Applicable
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT01715337
- Lead Sponsor
- Schön Klinik Berchtesgadener Land
- Brief Summary
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- chronic obstructive pulmonary disease
- FEV1%pred. < 50%
Exclusion Criteria
- acute exacerbation
- exacerbation in the last 4 weeks
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Change in the amount of capillaries in muscle fibre type I change from pre (day 1) to post rehabilitation (day 21)
- Secondary Outcome Measures
Name Time Method Change in the cross-sectional area of muscle fibre type IIa Change from pre (day 1) to post rehabilitation (day 21) Change in the amount of capillaries in muscle fibre type IIa Change from pre (day 1) to post rehabilitation (day 21) Change in the cross-sectional area of muscle fibre type I Change from pre (day 1) to post rehabilitation (day 21)
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie muscle fibre type transformation in COPD patients post pulmonary rehabilitation?
How does pulmonary rehabilitation compare to standard-of-care exercise regimens in improving quadriceps capillarization in COPD?
Which biomarkers correlate with changes in type II muscle fibre composition following 3-week pulmonary rehabilitation in COPD?
What adverse events are associated with high-intensity cycling and strength training in COPD rehabilitation programs?
Are there synergistic effects of combining pulmonary rehabilitation with anabolic agents like GH secretagogues in COPD muscle remodelling?
Trial Locations
- Locations (1)
Schön Klinik Berchtesgadener Land
🇩🇪Schönau am Königssee, Germany
Schön Klinik Berchtesgadener Land🇩🇪Schönau am Königssee, Germany