Effects of Pulmonary Rehabilitation on Skeletal Muscle Morphology and Metabolism in PiMM vs. PiZZ COPD Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Endurance time
研究概览
简要总结
In a former study, the investigator observed significant differences in the response to pulmonary rehabilitation between COPD patients with the "normal" genetic variant of alpha-1 antitrypsin (PiMM) and those with a homozygous deficient variant (PiZZ) (Jarosch et al., 2016, DOI: 10.1159/000449509). PiZZ COPD patients showed less improvement in exercise capacity compared to PiMM patients. This latter finding was mirrored by an increase of oxidative myofiber type I proportion - that is important for aerobic exercises in daily life - in PiMM but not PiZZ patients.
Based on this finding of impaired skeletal muscle adaptation, the aim of this study is to compare the effects of pulmonary rehabilitation including exercise training on a) specific enzymes of energy metabolism reflecting the oxidative capacity of the skeletal muscle and b) the analogue gene expression of these oxidative enzymes in a cohort of PiMM and PiZZ COPD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic obstructive pulmonary disease
- •phenotype PiMM or PiZZ
- •written informed consent
排除标准
- •any comorbidities that prevent patients from participating in an exercise Training program
- •necessity of anticoagulant therapy
- •other genetic variants of alpha-1 antitrypsin than PiMM or PiZZ
结局指标
主要结局
Endurance time
时间窗: 3 weeks
Will be measured during a constant work rate cycling test
次要结局
- Myofibre type I Distribution(3 weeks)
- Capillary to fibre ratio(3 weeks)
- muscle strength(3 weeks)
研究者
Klaus Kenn
Head physician, Department of Respiratory Medicine
Schön Klinik Berchtesgadener Land