Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital

Not yet recruiting

• Conditions: Liver Cirrhosis

• Registration Number: NCT06924294
• Lead Sponsor: Assiut University

Brief Summary

* To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.

* To evaluate the short-term outcomes of those patients.

Detailed Description

Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .

Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .

The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .

Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .

Study Timeline

• Study First Submitted: 2025-03-24
• Status Verified: 2025-04
• Study First Submitted QC: 2025-04-10
• Study First Posted: 2025-04-11
• Last Update Submitted: 2025-04-24
• Last Update Posted: 2025-04-27
• Study Start: 2025-06-01
• Primary Completion: 2025-11-30
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 290

Inclusion Criteria

• Patients with liver cirrhosis admitted to the department .

Exclusion Criteria

1. Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR <60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
2. Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In-hospital mortality	Through the study completion , average 6 months	Mortality during hospital stay
Phenotypes of acute kidney injury across geographic areas	Baseline ( at admission ), then through the study completion, average 6 months	Characteristics of acute kidney injury (clinical type and stage)

Secondary Outcome Measures

Name	Time	Method
28-day mortality	28 days	Mortality at 28 days
Resolution of AKI	Hospital stay (up to 90 days)	Resolution of AKI will be defined as return of serum creatinine to a value within 0.3 mg/di (26.5 mmol/L) of the baseline value. Partial response will be defined as regression of AKI to a lower stage with a reduction of serum creatinine to ≥0.3 mg/d\| (26.5 mmol/L) above the baseline value
Development of CKD	90 days	Chronic kidney disease will be defined as an estimated glomerular filtration rate \<60 ml/min ml/min/1.73 m2 for \>3 months. The Modification of Diet in Renal Disease equation will be used for estimating glomerular filtration rate

Trial Locations

Locations (1)

Al-Raghi liver hospital; 🇪🇬 Assiut, Assuit, Egypt