The role of high dose statins in the prevention of postoperative atrial fibrillation in patients undergoing cardiac surgery

Completed

• Conditions: Atrial fibrillation; Circulatory System

• Registration Number: ISRCTN41309956
• Lead Sponsor: St. George's Hospital Charitable Foundation (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-21
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

Patients undergoing elective first time Coronary Artery Bypass Graft (CABG) and/or Aortic Valve Replacement (AVR) will be randomised.

Exclusion Criteria

1. History of atrial arrhythmias
2. Hepatobiliary disease
3. Creatinine more than 180 mmol/l
4. Known intolerance of statins
5. Patients on long-term inhibitors of cytochrome P-450, history of AF, patients on treatment for anti-arrhythmic agents, except those on betablockers

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Atrial fibrillation

Secondary Outcome Measures

Name	Time	Method
Thromboembolic episodes (Transient Ischaemic Attacks [TIA]/CerebroVascular Accident [CVA])