Fructooligosaccharide and Calcium Absorption in Adolescent Girls

Phase 1

Completed

• Conditions: Osteoporosis
• Interventions: Dietary Supplement: Fructooligosaccharide

• Registration Number: NCT01005927
• Lead Sponsor: Purdue University

Brief Summary

Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01
• Primary Completion: 2009-06
• Study Completion: 2009-06
• Study First Submitted: 2009-10-30
• Study First Submitted QC: 2009-10-30
• Study First Posted: 2009-11-01
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-02
• Last Update Posted: 2018-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 26

Inclusion Criteria

• Female
• Calcium intake of 900-1300 mg/d
• Generally healthy

Exclusion Criteria

• Male
• BMI > 90th percentile for age
• Takes medication that influences calcium metabolism
• Any disorder of calcium or bone homeostasis (hypercalcemia, Paget's Disease)
• Smoking, illegal drug consumption
• Any gastrointestinal disease (Crohn's Disease, Celiac Disease, Inflammatory Bowel Disease)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
No Fructooligosaccharide	Fructooligosaccharide	0 g fructooligosaccharide added to calcium-containing beverage
3 g Fructooligosaccharide	Fructooligosaccharide	3 g fructooligosaccharide added to calcium-containing beverage

Primary Outcome Measures

Name	Time	Method
Fractional Calcium Absorption	24 h urine and 3 h blood

Secondary Outcome Measures

Name	Time	Method
Bone density and geometry measured with peripheral quantitative computed tomography (pQCT)	Initial visit

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States