Satiety Response of Four Dietary Fibers

Early Phase 1

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Control; Dietary Supplement: Soluble corn fiber; Dietary Supplement: Resistant starch; Dietary Supplement: Fructooligosaccharide; Dietary Supplement: Inulin

• Registration Number: NCT01233024
• Lead Sponsor: University of Minnesota

Brief Summary

Studies have found a relationship between dietary fiber consumption and body weight regulation. This relationship may stem from enhanced satiety through fermentation of certain fibers in the large intestine.

The objective of this study is to determine and compare satiety ratings, changes in food intake, and gastrointestinal effects for four fibers: fructooligosaccharide, inulin, soluble corn fiber, and resistant starch.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-05-28
• Study Start: 2010-11
• Study First Submitted QC: 2010-11-01
• Study First Posted: 2010-11-02
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-28
• Last Update Posted: 2012-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Healthy women
• Age 18-40 years
• Nonsmoking
• Not taking weight loss medications
• Non-dieting (weight has not changed more than 11 pounds over three months)
• BMI between 18.5 and 29
• Spoken and written English literacy

Exclusion Criteria

• Do not regularly consume breakfast
• Food allergies to wheat, soy, peanut, or dairy
• BMI less than 25 or greater than 29 upon admission to study
• Cancer diagnosis in past 5 years
• History of heart disease, kidney disease, diabetes, or eating disorder
• History of ulcerative colitis, Crohn's disease, or any other gastrointestinal condition
• History of drug or alcohol abuse in past 6 months
• Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
• Concurrent or recent (within 30 days) intervention study participation
• Pregnant or lactating
• Irregular menstrual cycle
• Vegetarians
• People who eat more than approximately 15 grams of fiber per day

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low fiber control	Control	no treatment dinner bar, no treatment breakfast bar
Promitor soluble corn fiber	Soluble corn fiber	12g in dinner bar, 11g in breakfast bar
FiberSym resistant starch	Resistant starch	12g in dinner bar, 11g breakfast bar
Orafti P95 fructooligosaccharide	Fructooligosaccharide	12g in dinner bar, 11g in breakfast bar
Orafti HPX inulin	Inulin	12g in dinner bar, 11g in breakfast bar

Primary Outcome Measures

Name	Time	Method
Satiety response using visual analogue scales	0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially	Satiety response will be measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Secondary Outcome Measures

Name	Time	Method
Food intake	180 minutes postprandially and over 24 hours
Breath hydrogen response	0 and 180 minutes
Gastrointestinal tolerance using visual analogue scales (VAS)	24 hours	Subjective ratings of bloating, stool consistency, and flatulence will be measured using VAS. A stool count will also be recorded.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Saint Paul, Minnesota, United States