Satiety Response of Short Chain Fructooligosaccharide

Early Phase 1

Completed

• Conditions: Healthy
• Interventions: Other: Placebo; Dietary Supplement: Short chain fructo-oligosaccharide (scFOS) 5 g; Dietary Supplement: Short chain fructooligosaccharide (scFOS) 8 g

• Registration Number: NCT01100788
• Lead Sponsor: University of Minnesota

Brief Summary

Populations that report high fiber consumption demonstrate lower rates of obesity. Enhanced satiety may play a key role in this relationship. The colonic fermentation of fibers is theorized to influence satiety and food intake. Short chain fructooligosaccharide (scFOS) are rapidly fermentable fibers that can easily be added to foods to impact these parameters.

The objective of this study was to evaluate the satiety response of scFOS and its ability to decrease food intake.

Detailed Description

Intervention study with fiber added to beverages and acute effects on satiety measured.

Study Timeline

• Study Start: 2009-03
• Primary Completion: 2009-06
• Study Completion: 2009-06
• Study First Submitted: 2010-03-05
• Status Verified: 2010-04
• Study First Submitted QC: 2010-04-08
• Last Update Submitted: 2010-04-08
• Study First Posted: 2010-04-09
• Last Update Posted: 2010-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy men and women
• Age 18-64 years
• Non-smoking
• Not taking medication
• Non-dieting (weight stable in prior 3 months)
• BMI 18-27
• English literacy

Exclusion Criteria

• Do not regularly consume breakfast
• Food allergies to ingredients found in study products
• BMI <18 or >27
• Diagnosed cardiovascular, renal, or hepatic disease diabetes mellitus
• Cancer in previous 5 years (except basal cell carcinoma of the skin)
• Any gastrointestinal disease or condition
• Recent bacterial infection (< 3 months)
• Recent or concurrent participation in an intervention research study
• History of drug or alcohol abuse in prior 6 months
• Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
• Eating disorder
• Vegetarians
• People who eat more than approximately 15 grams of fiber per day
• Women who are pregnant or lactating
• Women with irregular menstrual cycles

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	No treatment
scFOS 5 g	Short chain fructo-oligosaccharide (scFOS) 5 g	5 g scFOS
scFOS 8 g	Short chain fructooligosaccharide (scFOS) 8 g	8 g scFOS

Primary Outcome Measures

Name	Time	Method
Satiety response using visual analogue scales	0, 15, 30, 45, 60, 90, 120, 180, 240 minutes postprandially	Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Secondary Outcome Measures

Name	Time	Method
Ad libitum food intake	240 minutes postprandially and over 24 hours
Breath hydrogen response	0, 240 minutes
Gastrointestinal tolerance using visual analogue scales (VAS)	24 hours	Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Saint Paul, Minnesota, United States