Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obsessive Compulsive Disorder
- Sponsor
- University of Wisconsin, Milwaukee
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses. There is compelling evidence that poor response inhibition is a core cognitive feature of OCD and its related disorders, but no effective intervention exists that directly attempts to address this problematic cognitive deficiency. This study will examine the feasibility and clinical utility of a computerized cognitive training program designed to improve response inhibition among individuals diagnosed with OCD or trichotillomania.This training program offers systematic practice of response inhibition in the form of a 40-level computer game. Individuals with these conditions will be randomized to either 8 sessions of (a) computerized response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize that RIT will outperform PLT in improving response inhibition capabilities and reducing relevant clinical symptoms. In sum, this project is expected to generate important knowledge to guide the development of effective computer-based treatment approaches that may help reduce critical problems of existing treatments such as suboptimal patient retention and treatment under-utilization, thereby improving overall treatment response rates among individuals suffering from OCD and related conditions.
Investigators
Han Joo Lee
Assistant Professor
University of Wisconsin, Milwaukee
Eligibility Criteria
Inclusion Criteria
- •Principal diagnosis of obsessive-compulsive disorder or trichotillomania
Exclusion Criteria
- •Current substance use problems
- •Current/Past Psychotic disorder, bipolar disorder, or schizophrenia
- •Attention deficit/hyperactivity disorder or tic disorder
- •Severe depressive symptoms
- •Current psychotherapy
- •Current suicidality
- •Estimated intellectual functioning \< 80
- •Lack of response inhibition deficits on a stop-signal task
Outcomes
Primary Outcomes
Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH)
Time Frame: Baseline, Week 4, and Week 8
This is a clinician-administered rating scale of OCD symptom severity, most widely used in treatment outcome research for OCD, and a clinician-administered rating scale of hair pulling symptoms, widely used in clinical trial research for trichotillomania. Given the inclusion of two different diagnostic conditions, the primary outcome for the current study is the z score of the symptom rating severity obtained from the two rating scales, with higher values indicating greater symptom severity.
Stop Signal Reaction Time
Time Frame: Baseline, Week 4, and Week 8
Stop Signal Reaction Time (SSRT; time taken to complete the inhibitory process) is estimated using the tracking algorithm on the computerized stop-signal task, which adjusts the stop signal delay automatically (by 50ms) to maintain the rate of successful inhibition on stop-signal trials at 50%.
Secondary Outcomes
- Commission Errors on the Go/No-go Task.(Baseline, Week 4, and Week 8)
- Clinical Global Impression Severity and Improvement(Baseline, Week 4, and Week 8)