MedPath

Opioid Prescribing After Cesarean Delivery

Not Applicable
Completed
Conditions
Surgery
Opioid Use
Registration Number
NCT03168425
Lead Sponsor
Vanderbilt University Medical Center
Brief Summary

The number of opioid overdose deaths in the United States has quadrupled in 15 years, a dramatic manifestation of the current opioid abuse epidemic. This rise parallels a sharp increase in the amount of legal prescription opioids dispensed. The abundance of prescription opioids available is a primary pathway for opioid abuse and diversion. Adjusting post- cesarean delivery opioid prescribing practices to better match actual patient need has the potential to reduce unused opioids available for diversion, nonmedical use, and development of chronic dependence, as well as reduce wasted resources.

Detailed Description

Preliminary data from a quality improvement project performed in our department found that most women are prescribed opioids after discharge that were significantly in excess of the actual opioids used. However there is a subset of women (\~25%) who use all opioids and complain that they were not prescribed enough. The only variable predictive of post- discharge opioid use was Inpatient opioid use. These data were used to develop a formula for estimating outpatient use based on inpatient use. Currently there are no guidelines for outpatient prescribing either at our institution or on a national level. On average, most patients at our institution received 30 tablets of 5mg oxycodone at discharge. In surveying providers, very few looked at inpatient use and most had a standard prescription that they gave everyone.

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
190
Inclusion Criteria
  • Women 18-50 years old
  • Women undergoing cesarean delivery at a single institution
Exclusion Criteria
  • Major post-surgical complications: cesarean hysterectomy, bowl or bladder injury, reoperation, ICU admission, wound infection or separation
  • Chronic opioid use: Taking buprenorphine during pregnancy, taking an opioid for > 7 days during pregnancy.
  • Non English or Spanish speaking

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Unused Opioids4 weeks postpartum

oxycodone 5mg tablet leftover from prescription at discharge

Secondary Outcome Measures
NameTimeMethod
Pain: Frequency That Participants Reported Uncontrolled Pain4 weeks postpartum

Frequency that participants reported uncontrolled pain

Pain scores were examined based on how many negative responses indicating worse pain were reported to the five questions relating to analgesic adequacy. Thus participants could have a score that ranged from 0 to 5.

Question 1 - I was discharged with too few opioid pills (Yes=1, No=0) Question 2 - Overall, my pain is poorly controlled by these medications (Yes=1, No=0) Question 3 - Overall, my pain from delivery has been worse than expected (Yes=1, No=0) Question 4 - Pain interfered significantly with my ability to do normal activities (Yes=1, No=0) Question 5 - Since discharge, I needed more opioid than what was expected (Yes=1, No=0)

Trial Locations

Locations (1)

Sarah Osmundson

🇺🇸

Nashville, Tennessee, United States

Sarah Osmundson
🇺🇸Nashville, Tennessee, United States

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