se of a local anaesthetic wound infusion to reduce morphine requirements following major abdominal surgery

• Conditions: Pain; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)

• Registration Number: ACTRN12605000603617
• Lead Sponsor: Dr Simon Tomlinson, Department of Anaestheisa, Geelong Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

American Society of Anesthesiology (ASA) physical status 1, 2 or 3 patients undergoing elective major abdominal surgery via midline laparotomy at Geelong Hospital.

Exclusion Criteria

Pregnant; weight <50kg; allergy to morphine or amide local anaesthetics; ASA physical status 4; severe renal disease ( eGFR < 40ml/min ); significant hepatic impairment; severe respiratory disease (FEV1 < 1.0 l) cognitive impairment or a history of chronic opioid use. Furthermore, patients may be excluded from the trial immediately post-operatively if they meet any of the following criteria: patients who remain intubated post-operatively; post-operative renal or hepatic failure; morphine intolerance or major surgical complications requiring a return to theatre such as sepsis, bleeding or anastomotic breakdown.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Morphine PCA use[ Measured at 4, 24, 48, 72 hours post-op]

Secondary Outcome Measures

Name	Time	Method
Pain Scores at rest[ Measured at 4, 24, 48, 72 hours .];Coughing and sitting up Anti-emetic use Sedation scores.[ Measured at 4, 24, 48, 72 hours .]