The Effect of Sarcopenia on Hepatocellular Carcinoma After Hepatectomy
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Short-term postoperative results
研究概览
简要总结
By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after hepatectomy was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.
详细描述
All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes of patients after hepatectomy, the differences were analyzed and the relationship between sarcopenia and liver cancer was explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with preoperative clinical diagnosis of liver cancer
- •No cancer other than liver cancer has been diagnosed
- •Age ≥18 years
排除标准
- •Patients who could not complete the standard tests and questionnaires
- •Patients who did not accept liver resection after evaluation of treatment plan
- •Patients who had other concomitant preoperative causes of muscle weakness (injury, fracture, stroke, etc.)
- •Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)
结局指标
主要结局
Short-term postoperative results
时间窗: 3 months
Postoperative complications；90 days readmission rate
Long-term results after operation
时间窗: 10 years
Overall survival; Disease free survival
次要结局
- Postoperative hospitalization time(2 months)
- Hospitalization expenses(2 months)
研究者
Gang Chen, MD
Clinical Professor, Principal Investigator
First Affiliated Hospital of Wenzhou Medical University