Relationship Between Liver Cancer and Sarcopenia

• Conditions: Sarcopenia; Liver Cancer

• Registration Number: NCT05339919
• Lead Sponsor: First Affiliated Hospital of Wenzhou Medical University

Brief Summary

By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after hepatectomy was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.

Detailed Description

All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes of patients after hepatectomy, the differences were analyzed and the relationship between sarcopenia and liver cancer was explored.

Study Timeline

• Study Start: 2020-05-01
• Primary Completion: 2021-08-11
• Study First Submitted: 2022-04-09
• Study First Submitted QC: 2022-04-15
• Study First Posted: 2022-04-21
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-14
• Last Update Posted: 2022-06-15
• Study Completion: 2025-08-28

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Patients with preoperative clinical diagnosis of liver cancer
• No cancer other than liver cancer has been diagnosed
• Age ≥18 years

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Exclusion Criteria

• Patients who could not complete the standard tests and questionnaires
• Patients who did not accept liver resection after evaluation of treatment plan
• Patients who had other concomitant preoperative causes of muscle weakness (injury, fracture, stroke, etc.)
• Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Short-term postoperative results	3 months	Postoperative complications；90 days readmission rate
Long-term results after operation	10 years	Overall survival; Disease free survival

Secondary Outcome Measures

Name	Time	Method
Postoperative hospitalization time	2 months	Time window from the day of operation to the day of discharge.
Hospitalization expenses	2 months	All hospitalization expenses, including drug expenses, operation expenses, anesthesia expenses, nursing expenses and other expenses.

Trial Locations

Locations (1)

Gang Chen; 🇨🇳 Wenzhou, Zhejiang, China